ReviewJournal of cellular and molecular medicine2009
Current evidence for a modulation of low back pain by human genetic variants.
Review in Journal of cellular and molecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genes associated with persistent lumbar radicular pain; a systematic review.BMC musculoskeletal disorders · 2016Pooled it
- Trial
- Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures.PloS one · 2011Trial
- Intervertebral disc degeneration is accelerated by GH overexpression but attenuated by GH antagonism.GeroScience · 2026Article
- Does Combining the STarT Back Tool With a Polygenic Risk Score for Chronic Low Back Pain Improve Prediction of Work Disability Over 2 Years?European journal of pain (London, England) · 2026Article
- Predicting the Risk of Lumbar Prolapsed Disc: A Gene Signature-Based Machine Learning Analysis.Pain and therapy · 2025Article
- The role of micronutrients and serum metabolites in intervertebral disk degeneration: insights from a Mendelian randomization study and mediation analysis.Frontiers in nutrition · 2024Article
- Non-spinal low back pain: Global epidemiology, trends, and risk factors.Health science reports · 2023Article
- Theoretical Schemas to Guide Back Pain Consortium (BACPAC) Chronic Low Back Pain Clinical Research.Pain medicine (Malden, Mass.) · 2023Review
- Effects of Sex and Obesity onInternational journal of molecular sciences · 2022Article
- Risk factors for low back pain outcome: Does it matter when they are measured?European journal of pain (London, England) · 2022Article
- Alterations in ECM signature underscore multiple sub-phenotypes of intervertebral disc degeneration.Matrix biology plus · 2020Article
- Cytotoxic Immunity in Peripheral Nerve Injury and Pain.Frontiers in neuroscience · 2020Review
- Persistent lumbar radicular and low back pain; impact of genetic variability versus emotional distress.BMC research notes · 2019Article
- LncRNA-RMRP promotes nucleus pulposus cell proliferation through regulating miR-206 expression.Journal of cellular and molecular medicine · 2018Article
- A machine-learned analysis of human gene polymorphisms modulating persisting pain points to major roles of neuroimmune processes.European journal of pain (London, England) · 2018Article
- Long non-coding RNAs in nucleus pulposus cell function and intervertebral disc degeneration.Cell proliferation · 2018Review
- Intervertebral disc development and disease-related genetic polymorphisms.Genes & diseases · 2016Review
- The efficacy of manual therapy and exercise for different stages of non-specific low back pain: an update of systematic reviews.The Journal of manual & manipulative therapy · 2014Article
- Genetic polymorphisms of interleukin-1 alpha and the vitamin d receptor in mexican mestizo patients with intervertebral disc degeneration.International journal of genomics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The manifestation of chronic back pain depends on structural, psychosocial, occupational and genetic influences. Heritability estimates for back pain range from 30% to 45%. Genetic influences are caused by genes affecting intervertebral disc degeneration or the immune response and genes involved in pain perception, signalling and psychological processing. This inter-individual variability which is partly due to genetic differences would require an individualized pain management to prevent the transition from acute to chronic back pain or improve the outcome. The genetic profile may help to define patients at high risk for chronic pain. We summarize genetic factors that (i) impact on intervertebral disc stability, namely Collagen IX, COL9A3, COL11A1, COL11A2, COL1A1, aggrecan (AGAN), cartilage intermediate layer protein, vitamin D receptor, metalloproteinsase-3 (MMP3), MMP9, and thrombospondin-2, (ii) modify inflammation, namely interleukin-1 (IL-1) locus genes and IL-6 and (iii) and pain signalling namely guanine triphosphate (GTP) cyclohydrolase 1, catechol-O-methyltransferase, mu opioid receptor (OPMR1), melanocortin 1 receptor (MC1R), transient receptor potential channel A1 and fatty acid amide hydrolase and analgesic drug metabolism (cytochrome P450 [CYP]2D6, CYP2C9).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.