ArticleBiopolymers2009
Trifluoroethanol reveals helical propensity at analogous positions in cytoplasmic domains of three connexins.
Article in Biopolymers, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke.International journal of molecular sciences · 2021Article
- Evaluation of Host Defense Peptide (CaD23)-Antibiotic Interaction and Mechanism of Action: Insights From Experimental and Molecular Dynamics Simulations Studies.Frontiers in pharmacology · 2021Article
- Co-translational folding of α-helical proteins: structural studies of intermediate-length variants of the λ repressor.FEBS open bio · 2018Article
- Structural studies of the N-terminal fragments of the WW domain: Insights into co-translational folding of a beta-sheet protein.Scientific reports · 2016Article
- Secondary structural analysis of the carboxyl-terminal domain from different connexin isoforms.Biopolymers · 2016Article
- The cytosolic tail of the tumor marker protein Trop2--a structural switch triggered by phosphorylation.Scientific reports · 2015Article
- Characterization of the connexin45 carboxyl-terminal domain structure and interactions with molecular partners.Biophysical journal · 2014Article
- Structural order in Pannexin 1 cytoplasmic domains.Channels (Austin, Tex.) · 2014Article
- Calmodulin dependent protein kinase increases conductance at gap junctions formed by the neuronal gap junction protein connexin36.Brain research · 2012Article
- Structure and functional studies of N-terminal Cx43 mutants linked to oculodentodigital dysplasia.Molecular biology of the cell · 2012Article
- Mechanism for modulation of gating of connexin26-containing channels by taurine.The Journal of general physiology · 2011Article
- Amino acid residue Val362 plays a critical role in maintaining the structure of C terminus of connexin 50 and in lens epithelial-fiber differentiation.The Journal of biological chemistry · 2010Article
- Optimizing the solution conditions to solve the structure of the Connexin43 carboxyl terminus attached to the 4(th) transmembrane domain in detergent micelles.Cell communication & adhesion · 2010Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cytoplasmic domains of gap junction proteins (connexins) are involved in channel gating, voltage and pH sensitivity, and contain binding sites for partner proteins. However, their secondary structure is incompletely characterized and comparisons among the connexins is totally lacking. Circular dichroism (CD) was used to study the conformational properties of synthetic peptides corresponding to the highly divergent amino acid sequences of cytoplasmic domains of connexin (Cx)32, Cx36, and Cx43. We report that whereas peptides were largely unstructured in aqueous buffer, certain peptides in 30% trifluoroethanol (TFE) showed considerable helical content. These structured peptides correspond to analogous regions in each of the three connexin cytoplasmic domains. This first comparative study of conformational properties of connexin cytoplasmic domains reveals protein domains that may play similar roles in channel function and protein-protein interactions.
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