ArticleThe Journal of comparative neurology2009
Chronic low-level lead exposure affects the monoaminergic system in the mouse superior olivary complex.
Article in The Journal of comparative neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- Glutamate-Mediated Neural Alterations in Lead Exposure: Mechanisms, Pathways, and Phenotypes.Toxics · 2025Review
- Lead exposure induces nitrative stress and disrupts ribbon synapses in the cochlea.Frontiers in molecular neuroscience · 2022Article
- Combined Exposure to Metals in Drinking Water Alters the Dopamine System in Mouse Striatum.International journal of environmental research and public health · 2021Article
- Lead (Pb) exposure induces dopaminergic neurotoxicity inToxicology reports · 2019Article
- Chronic lead exposure induces cochlear oxidative stress and potentiates noise-induced hearing loss.Toxicology letters · 2018Article
- Assessing ototoxicity due to chronic lead and cadmium intake with and without noise exposure in the mature mouse.Journal of toxicology and environmental health. Part A · 2018Article
- Pb exposure prolongs the time period for postnatal transient uptake of 5-HT by murine LSO neurons.Neurotoxicology · 2016Article
- Blood lead concentrations and attention deficit hyperactivity disorder in Korean children: a hospital-based case control study.BMC pediatrics · 2016Article
- Development of early-born γ-Aminobutyric acid hub neurons in mouse hippocampus from embryogenesis to adulthood.The Journal of comparative neurology · 2016Article
- Perceptual Training Restores Impaired Cortical Temporal Processing Due to Lead Exposure.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Serum neuron-specific enolase, biogenic amino-acids and neurobehavioral function in lead-exposed workers from lead-acid battery manufacturing process.The international journal of occupational and environmental medicine · 2015Article
- Influence of lead on repetitive behavior and dopamine metabolism in a mouse model of iron overload.Toxicological research · 2014Article
- Novel dose-dependent alterations in excitatory GABA during embryonic development associated with lead (Pb) neurotoxicity.Toxicology letters · 2014Article
- Nuclei-specific differences in nerve terminal distribution, morphology, and development in mouse visual thalamus.Neural development · 2014Article
- Distribution of language-related Cntnap2 protein in neural circuits critical for vocal learning.The Journal of comparative neurology · 2014Article
- Distribution of VGLUT3 in highly collateralized axons from the rat dorsal raphe nucleus as revealed by single-neuron reconstructions.PloS one · 2014Article
- Development of the serotonergic cells in murine raphe nuclei and their relations with rhombomeric domains.Brain structure & function · 2013Article
- Columnar distribution of catecholaminergic neurons in the ventrolateral periaqueductal gray and their relationship to efferent pathways.Synapse (New York, N.Y.) · 2013Article
- A method for the three-dimensional reconstruction of Neurobiotin™-filled neurons and the location of their synaptic inputs.Frontiers in neural circuits · 2013Article
- Increased hippocampal Disrupted-In-Schizophrenia 1 expression in mice exposed prenatally to lead.Neural regeneration research · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Low-level lead (Pb) exposure is associated with behavioral and cognitive dysfunction, but it is not clear how Pb produces these behavioral changes. Pb has been shown to alter auditory temporal processing in both humans and animals. Auditory temporal processing occurs in the superior olivary complex (SOC) in the brainstem, where it is an important component in sound detection in noisy environments and in selective auditory attention. The SOC receives a serotonergic innervation from the dorsal raphe, and serotonin has been implicated in auditory temporal processing within the brainstem and inferior colliculus. Because Pb exposure modulates auditory temporal processing, the serotonergic system is a potential target for Pb. The current study was undertaken to determine whether developmental Pb exposure preferentially changes the serotonergic system within the SOC. Pb-treated mice were exposed to no Pb, very low Pb (0.01 mM), or low Pb (0.1 mM) throughout gestation and through 21 days postnatally. Brainstem sections from control and Pb-exposed mice were immunostained for the vesicular monoamine transporter 2 (VMAT2), serotonin (5-HT), and dopamine-beta-hydroxylase (DbetaH; a marker for norepinephrine) in order to elucidate the effect of Pb on monoaminergic input into the SOC. Sections were also immunolabeled with antibodies to vesicular glutamate transporter 1 (VGLUT1), vesicular gamma-aminobutyric acid (GABA) transporter (VGAT), and vesicular acetylcholine transporter (VAChT) to determine whether Pb exposure alters the glutaminergic, GABAergic, or cholinergic systems. Pb exposure caused a significant decrease in VMAT2, 5-HT, and DbetaH expression, whereas VGLUT1, VGAT, and VAChT showed no change. These results provide evidence that Pb exposure during development alters normal monoaminergic expression in the auditory brainstem.
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