ArticlePLoS biology2009
Genome-wide control of the distribution of meiotic recombination.
Article in PLoS biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 78 citations in OpenAlex.
- Digital Image Processing to Detect Adaptive Evolution.Molecular biology and evolution · 2024Article
- FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loading.Nature communications · 2024Article
- Cytological Analysis of Crossover Frequency and Distribution in Male Meiosis of Cardueline Finches (Fringillidae, Aves).Animals : an open access journal from MDPI · 2023Article
- TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks.Nature communications · 2022Article
- Oocyte Casein kinase 1α deletion causes defects in primordial follicle formation and oocyte loss by impairing oocyte meiosis and enhancing autophagy in developing mouse ovary.Cell death discovery · 2022Article
- Article
- Sex chromosome quadrivalents in oocytes of the African pygmy mouse Mus minutoides that harbors non-conventional sex chromosomes.Chromosoma · 2019Article
- In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice.Communications biology · 2019Article
- PRDM9, a driver of the genetic map.PLoS genetics · 2018Review
- The PRDM9 KRAB domain is required for meiosis and involved in protein interactions.Chromosoma · 2017Article
- In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites.Genome research · 2017Article
- SKAP, an outer kinetochore protein, is required for mouse germ cell development.Reproduction (Cambridge, England) · 2016Article
- Physiology of the read-write genome.The Journal of physiology · 2014Review
- The Drosophila early ovarian transcriptome provides insight to the molecular causes of recombination rate variation across genomes.BMC genomics · 2013Article
- t-SNARE Syntaxin2 (STX2) is implicated in intracellular transport of sulfoglycolipids during meiotic prophase in mouse spermatogenesis.Biology of reproduction · 2013Article
- The effects of DNA double-strand breaks on mouse oocyte meiotic maturation.Cell cycle (Georgetown, Tex.) · 2013Article
- Chromatin remodeling, DNA damage repair and aging.Current genomics · 2012Article
- Article
- Deficiency in DNA methylation increases meiotic crossover rates in euchromatic but not in heterochromatic regions in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The many landscapes of recombination in Drosophila melanogaster.PLoS genetics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meiotic recombination events are not randomly distributed in the genome but occur in specific regions called recombination hotspots. Hotspots are predicted to be preferred sites for the initiation of meiotic recombination and their positions and activities are regulated by yet-unknown controls. The activity of the Psmb9 hotspot on mouse Chromosome 17 (Chr 17) varies according to genetic background. It is active in strains carrying a recombinant Chr 17 where the proximal third is derived from Mus musculus molossinus. We have identified the genetic locus required for Psmb9 activity, named Dsbc1 for Double-strand break control 1, and mapped this locus within a 6.7-Mb region on Chr 17. Based on cytological analysis of meiotic DNA double-strand breaks (DSB) and crossovers (COs), we show that Dsbc1 influences DSB and CO, not only at Psmb9, but in several other regions of Chr 17. We further show that CO distribution is also influenced by Dsbc1 on Chrs 15 and 18. Finally, we provide direct molecular evidence for the regulation in trans mediated by Dsbc1, by showing that it controls the CO activity at the Hlx1 hotspot on Chr 1. We thus propose that Dsbc1 encodes for a trans-acting factor involved in the specification of initiation sites of meiotic recombination genome wide in mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.