ArticleMolecular and cellular biochemistry2009
YB-1 transcription in the postnatal brain is regulated by a bHLH transcription factor Math2 through an E-box sequence in the 5'-UTR of the gene.
Article in Molecular and cellular biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 13 citations in OpenAlex.
- Homodimeric and Heterodimeric Interactions among Vertebrate Basic Helix-Loop-Helix Transcription Factors.International journal of molecular sciences · 2021Review
- YB-1 synthesis is regulated by mTOR signaling pathway.PloS one · 2012Article
- YB-1 binds to GluR2 mRNA and CaM1 mRNA in the brain and regulates their translational levels in an activity-dependent manner.Cellular and molecular neurobiology · 2010Article
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4 authors at 1 institution in 1 country.
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Abstract
YB-1 controls gene expression at both the transcriptional and translational levels. In the brain, a high level of YB-1 is expressed from prior to the first week after birth. However, YB-1 expression substantially declines to the adult level thereafter. Here, we investigated the regulatory mechanism of YB-1 transcription in the postnatal brain. We found that an E-box sequence within the 5'-untranslated region (5'-UTR) of the gene was recognized by Math2 in the 5-day-old brain, whereas the DNA binding was reduced in the 4-week-old brain. In vitro transcription analysis and reporter gene assay revealed that Math2 was necessary for YB-1 transcription. Furthermore, the expression pattern of Math2 protein in the postnatal brain was correlated with that of YB-1 protein. Our results suggest that YB-1 transcription in the postnatal brain is regulated by Math2, which binds to an E-box in the 5'-UTR of the YB-1 gene.
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