ArticleOrganic & biomolecular chemistry2009
Sugar nucleotide recognition by Klebsiella pneumoniae UDP-D-galactopyranose mutase: fluorinated substrates, kinetics and equilibria.
Article in Organic & biomolecular chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 39 citations in OpenAlex.
- Vertirhodins A-F, C-Linked Pyrrolidine-Iminosugar-Containing Pyranonaphthoquinones fromOrganic letters · 2021Article
- Exploring the Glycans of Euglena gracilis.Biology · 2017Article
- Enzymatic synthesis of nucleobase-modified UDP-sugars: scope and limitations.Carbohydrate research · 2015Article
- A one-pot enzymatic approach to the O-fluoroglucoside of N-methylanthranilate.Bioorganic & medicinal chemistry · 2013Article
- Multigramme synthesis and asymmetric dihydroxylation of a 4-fluorobut-2E-enoate.Beilstein journal of organic chemistry · 2013Article
- Studies on the substrate specificity of a GDP-mannose pyrophosphorylase from Salmonella enterica.Beilstein journal of organic chemistry · 2012Article
- Peracetylated alpha-D-glucopyranosyl fluoride and peracetylated alpha-maltosyl fluoride.Acta crystallographica. Section C, Crystal structure communications · 2010Article
- Characterization of a bifunctional pyranose-furanose mutase from Campylobacter jejuni 11168.The Journal of biological chemistry · 2010Article
- Ligand binding and substrate discrimination by UDP-galactopyranose mutase.Journal of molecular biology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
Abstract
A series of selectively fluorinated and other substituted UDP-D-galactose derivatives have been evaluated as substrates for Klebsiella pneumoniae UDP-D-galactopyranose mutase. This enzyme, which catalyses the interconversion of the pyranose and furanose forms of galactose as its UDP adduct, is a prospective drug target for a variety of microbial infections. We show that none of the 2''-, 3''- or 6''-hydroxyl groups of UDP-D-galactopyranose are essential for substrate binding and turnover. However, steric factors appear to play an important role in limiting the range of substitutions that can be accommodated at C-2'' and C-6'' of the sugar nucleotide substrate. Attempts to invert the C-2'' stereochemistry from equatorial to axial, changing D-galacto- to D-talo-configuration, in an attempt to exploit the higher percentage of furanose at equilibrium in the talo-series, met with no turnover of substrate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.