ReviewGene therapy2009
Progress and prospects: techniques for site-directed mutagenesis in animal models.
Review in Gene therapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Leverage of nuclease-deficient CasX for preventing pathological angiogenesis.Molecular therapy. Nucleic acids · 2023Article
- Assessment of Mosaicism and Detection of Cryptic Alleles in CRISPR/Cas9-Engineered Neurofibromatosis Type 1 andFrontiers in genetics · 2021Article
- Engineering animal models of dystonia.Movement disorders : official journal of the Movement Disorder Society · 2013Review
- Performance of computational tools in evaluating the functional impact of laboratory-induced amino acid mutations.Bioinformatics (Oxford, England) · 2012Article
- Gucy2f zebrafish knockdown--a model for Gucy2d-related leber congenital amaurosis.European journal of human genetics : EJHG · 2012Article
- Zinc finger protein-dependent and -independent contributions to the in vivo off-target activity of zinc finger nucleases.Nucleic acids research · 2011Article
- Transgenic pigs as models for translational biomedical research.Journal of molecular medicine (Berlin, Germany) · 2010Review
- Cilia localization is essential for in vivo functions of the Joubert syndrome protein Arl13b/Scorpion.Development (Cambridge, England) · 2009Article
- Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling.Nature reviews. Genetics · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In the past 2 years, new gene-targeting approaches using adeno-associated virus and designer zinc-finger nucleases have been successfully applied to the production of genetically modified ferrets, pigs, mice and zebrafish. Gene targeting using these tools has been combined with somatic cell nuclear transfer and germ cell transplantation to generate gene-targeted animal models. These new technical advances, which do not require the generation of embryonic stem cell-derived chimeras, will greatly accelerate the production of non-mouse animal models for biomedical research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.