ArticleThe American journal of clinical nutrition2009
Population differences in associations between C-reactive protein concentration and adiposity: comparison of young adults in the Philippines and the United States.
Article in The American journal of clinical nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Comparative Efficacy of Pharmacological Interventions for Heart Failure with Reduced Ejection Fraction Between Asian and White Patients: A Meta-analysis of Randomized Controlled Trials.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2025Pooled it
- Evaluation of a DNA methylation-based measure of chronic inflammation in two generations of adults in metropolitan Cebu, Philippines.Scientific reports · 2025Article
- Helicobacter pylori in the Philippines: Social and Ecological Determinants of Seropositivity and Lack of Association With Systemic Inflammation.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Lower Socioeconomic Status Predicts Increased Proinflammatory Signaling in Late Pregnancy: Evidence From a Filipino Cohort.American journal of human biology : the official journal of the Human Biology Council · 2024Article
- Article
- Intimate partner violence, depression, and chronic low-grade inflammation among middle-aged women in Cebu, Philippines.American journal of human biology : the official journal of the Human Biology Council · 2024Article
- Pregnancy is linked to faster epigenetic aging in young women.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Three common assumptions about inflammation, aging, and health that are probably wrong.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- C-reactive protein in adult Samoans: Population variation and physiological correlates.American journal of human biology : the official journal of the Human Biology Council · 2022Article
- Early life, life course and gender influences on levels of C-reactive protein among migrant Bangladeshis in the UK.Evolution, medicine, and public health · 2022Article
- Gender Minority Stress, Support, and Inflammation in Transgender and Gender-Nonconforming Youth.Transgender health · 2021Article
- Modified neutrophil-platelet score as a promising marker for stratified surgical and oncological outcomes of patients with gastric cancer.Surgery today · 2020Article
- The Challenge by Multiple Environmental and Biological Factors Induce Inflammation in Aging: Their Role in the Promotion of Chronic Disease.Frontiers in immunology · 2020Review
- Innate food aversions and culturally transmitted food taboos in pregnant women in rural southwest India: separate systems to protect the fetus?Evolution and human behavior : official journal of the Human Behavior and Evolution Society · 2017Article
- Social and physical environments early in development predict DNA methylation of inflammatory genes in young adulthood.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Factors associated with inflammation in preschool children and women of reproductive age: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project.The American journal of clinical nutrition · 2017Review
- No association between blood telomere length and longitudinally assessed diet or adiposity in a young adult Filipino population.European journal of nutrition · 2017Article
- Energetics and the immune system: Trade-offs associated with non-acute levels of CRP in adolescent Gambian girls.Evolution, medicine, and public health · 2017Article
- Pathogen-Host Defense in the Evolution of Depression: Insights into Epidemiology, Genetics, Bioregional Differences and Female Preponderance.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Predictors of Inflammation in a Cohort of Bolivian Infants and Toddlers.The American journal of tropical medicine and hygiene · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundInflammation may be an important mediator of the association between nutrition and cardiovascular diseases, but most studies have been conducted in Western populations with high rates of overweight and obesity and low levels of infectious disease.
objectivesThis study sought to investigate the predictors of C-reactive protein (CRP) in young adults living in the Philippines and to examine patterns of association with adiposity compared with young adults in the United States.
designMaximum likelihood logistic regression models were used to predict elevated high-sensitivity CRP (>3 mg/L) in relation to anthropometric measures of adiposity, symptoms of infectious disease, and proxy measures of pathogen exposure in men and women from the Philippines (n = 1648; age: 20-22 y). Comparative data were drawn from a nationally representative sample in the United States (National Health and Nutrition Examination Survey; n = 616; age: 19-24 y).
resultsMedian concentrations of CRP were substantially lower in the Philippines (0.2 mg/L) than in the United States (0.9 mg/L), and the likelihood of elevated CRP was lower in the Philippines than in the United States at the same level of waist circumference or skinfold thickness. In the Philippines, infectious symptoms and pathogen exposure predicted elevated CRP, independent of adiposity.
conclusionsAdiposity and infectious exposures are associated with elevated CRP in the Philippines; other populations undergoing comparable lifestyle and dietary changes associated with increasing rates of overweight and obesity are likely experiencing similar double burdens of inflammatory stimuli. Low concentrations of CRP in this Philippine sample raise the question of whether CRP cutoffs based on European or European-American reference populations are appropriate for predicting disease risk in populations undergoing the nutrition transition.
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Registered trials
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