Evidence map›Paper›PMID 19225101›Full record

ArticleJournal of clinical microbiology2009

Nevirapine resistance in human immunodeficiency virus type 1-positive infants determined using dried blood spots stored for up to six years at room temperature.

Julie A E Nelson, Amy M Loftis, Deborah Kamwendo, Wafaie W Fawzi, Taha E Taha, Robert L Goldenberg, Susan A Fiscus

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Julie A E NelsonDepartment of Microbiology and Immunology, UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. jnelson@med.unc.edu
Amy M Loftis
Deborah Kamwendo
Wafaie W Fawzi
Taha E Taha
Robert L Goldenberg
Susan A Fiscus
University of North Carolina at Chapel Hill · USDrexel University · USHarvard University · USJohns Hopkins University · US

Funding

International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) GroupU01AI068632 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI JACKSON, J BROOKS · 2006 to 2010
$109.7M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
HIV PREVENTION TRIALS UNIT--MALAWIU01AI048005 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TAHA, TAHA E · 2000 to 2006
$37.6M
UAB-ZAMBIA-HAITI HIV PREVENTION TRIALS UNITU01AI047972 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STRINGER, JEFFREY SAMUEL ALLEN · 2000 to 2006
$16.5M
HIV PREVENTION TRIALS UNITU01AI048006 · NIAID · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI FAWZI, WAFAIE W · 2000 to 2005
$14.3M
STATISTICAL &CLINICAL COORDINATING CENTER (SC)N01AI045200 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SELF, STEVEN G. · 1994 to 2000
$853k
INTNL.VACC.EFFICACY TRIALS MASTER CONTRACT (IMC)N01AI035173 · NIAID · FAMILY HEALTH INTERNATIONAL · PI CATES, WILLARD · 1993 to 2000
$0k
NIAID NIH HHS N01 AI035173NIAID NIH HHS N01 AI045200NIAID NIH HHS N01-AI-35173-117/412NIAID NIH HHS P30 AI050410NIAID NIH HHS P30AI50410NIAID NIH HHS U01 AI047972NIAID NIH HHS U01 AI048005NIAID NIH HHS U01 AI048006NIAID NIH HHS U01 AI068632NIAID NIH HHS U01AI068632NIAID NIH HHS U01-AI-47972NIAID NIH HHS U01-AI-48005NIAID NIH HHS U01-AI-48006
6 · The paper itself

Abstract

Dried blood spots that had been stored ambiently for 3 to 6 years lost approximately 1 log(10) of human immunodeficiency virus type 1 (HIV-1) RNA, but the majority could still be genotyped for resistance. Nevirapine resistance was found in 7/16 (43.5%) HIV-1-positive HIVNET 024 infants at 4 to 6 weeks, but no resistance was found at other time points.

Indexed as

Drug Resistance, ViralAnti-HIV AgentsBloodDesiccationGenotypeHIV-1HumansInfantInfant, NewbornNevirapineRNA, ViralSpecimen HandlingTemperatureAnti-HIV AgentsNevirapineRNA, Viral

Identifiers

PMID19225101
PMCPMC2668311
OpenAlexW2112690333

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.