ArticleJournal of virology2009
Densovirus infectious pathway requires clathrin-mediated endocytosis followed by trafficking to the nucleus.
Article in Journal of virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- A Novel Parvovirus Associated with the WhiteflyPathogens (Basel, Switzerland) · 2025Article
- Deep Sequencing Analysis of Virome Components, Viral Gene Expression and Antiviral RNAi Responses inInternational journal of molecular sciences · 2024Article
- Article
- Bipartite genome and structural organization of the parvovirus Acheta domesticus segmented densovirus.Nature communications · 2023Article
- Article
- Evolution and phylogeography ofVirus evolution · 2019Article
- Intracellular Localization ofViruses · 2018Article
- Proteomics reveals novel protein associations with early endosomes in an epidermal growth factor-dependent manner.The Journal of biological chemistry · 2018Article
- Protoparvovirus Cell Entry.Viruses · 2017Review
- Role of the phosphatidylinositol-3-kinase/Akt/target of rapamycin pathway during ambidensovirus infection of insect cells.The Journal of general virology · 2016Article
- In vitro and in vivo host range of Anopheles gambiae densovirus (AgDNV).Scientific reports · 2015Article
- Coat as a dagger: the use of capsid proteins to perforate membranes during non-enveloped DNA viruses trafficking.Viruses · 2014Review
- Influenza entry pathways in polarized MDCK cells.Biochemical and biophysical research communications · 2014Article
- Parvovirus particles and movement in the cellular cytoplasm and effects of the cytoskeleton.Virology · 2014Article
- Densovirus crosses the insect midgut by transcytosis and disturbs the epithelial barrier function.Journal of virology · 2013Article
- Characterization of the early steps of human parvovirus B19 infection.Journal of virology · 2012Article
- Four amino acids of an insect densovirus capsid determine midgut tropism and virulence.Journal of virology · 2012Article
- Alzheimer's disease gene signature says: beware of brain viral infections.Immunity & ageing : I & A · 2010Article
- A recombinant AeDNA containing the insect-specific toxin, BmK IT1, displayed an increasing pathogenicity on Aedes albopictus.The American journal of tropical medicine and hygiene · 2010Article
- Multiple pathways involved in porcine parvovirus cellular entry and trafficking toward the nucleus.Journal of virology · 2010Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Junonia coenia densovirus (JcDNV) is an ambisense insect parvovirus highly pathogenic for lepidopteran pests at larval stages. The potential use of DNVs as biological control agents prompted us to reinvestigate the host range and cellular mechanisms of infection. In order to understand the early events of infection, we set up a functional infection assay in a cell line of the pest Lymantria dispar to determine the intracellular pathway undertaken by JcDNV to infect a permissive lepidopteran cell line. Our results show that JcDNV particles are rapidly internalized into clathrin-coated vesicles and slowly traffic within early and late endocytic compartments. Blocking late-endocytic trafficking or neutralizing the pH with drugs inhibited infection. During internalization, disruption of the cytoskeleton, and inhibition of phosphatidylinositol 3-kinase blocked the movement of vesicles containing the virus to the nucleus and impaired infection. In summary, our results define for the first time the early endocytic steps required for a productive DNV infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.