ArticleJournal of assisted reproduction and genetics2009
Aneuploidy in abortuses following IVF and ICSI.
Article in Journal of assisted reproduction and genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06762704 (A Non-Invasive Artificial Intelligence Model for the Prediction of Human Blastocyst Ploidy), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Non-Invasive Artificial Intelligence Model for the Prediction of Human Blastocyst Ploidy: a Multi-Center, Prospective, Non-Randomized Validation Study
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Risk of chromosomal abnormalities in early spontaneous abortion after assisted reproductive technology: a meta-analysis.PloS one · 2013Pooled it
- Comparison of chromosomal abnormality rates in ICSI for non-male factor and spontaneous conception.Journal of assisted reproduction and genetics · 2012Trial
- The Association Between Mature Oocyte Proportion and IVF Success: A Retrospective Analysis of 2,565 ICSI Cycles.Journal of reproduction & infertility · 2025Article
- Conventional in vitro fertilization enhances preimplantation genetic testing for aneuploidy outcomes in couples with non-male factor infertility.Scientific reports · 2025Article
- Non-invasively predicting euploidy in human blastocysts via quantitative 3D morphology measurement: a retrospective cohort study.Reproductive biology and endocrinology : RB&E · 2024Article
- Intracytoplasmic sperm injection versus conventional in vitro fertilization in unexplained infertility.F&S reports · 2024Article
- Chromosomal analysis of 262 miscarried conceptuses: a retrospective study.BMC pregnancy and childbirth · 2022Article
- Karyotype of the Blastocoel Fluid Derived by Laser-Assisted Hatching Demonstrates a Low Agreement With the Trophectoderm.Frontiers in physiology · 2022Article
- Article
- Some of the Factors Involved in Male Infertility: A Prospective Review.International journal of general medicine · 2020Review
- Does ICSI for in vitro fertilization cause more aneuploid embryos?Molecular cytogenetics · 2020Article
- Paternal contribution to embryonic competence.Central European journal of urology · 2019Article
- Effect of assisted reproductive technology on the molecular karyotype of missed abortion tissues.Bioscience reports · 2018Article
- Intracytoplasmic sperm injection for male infertility and consequences for offspring.Nature reviews. Urology · 2018Review
- Correlation analysis between ultrasound findings and abnormal karyotypes in the embryos from early pregnancy loss after in vitro fertilization-embryo transfer.Journal of assisted reproduction and genetics · 2017Article
- A twin sibling with Prader-Willi syndrome caused by type 2 microdeletion following assisted reproductive technology: A case report.Biomedical reports · 2016Article
- Molecular cytogenetic analysis of early spontaneous abortions conceived from varying assisted reproductive technology procedures.Molecular cytogenetics · 2016Article
- Amino acid turnover by human oocytes is influenced by gamete developmental competence, patient characteristics and gonadotrophin treatment.Human reproduction (Oxford, England) · 2013Article
- Chromosomal abnormalities in spontaneous abortion after assisted reproductive treatment.BMC medical genetics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare aneuploidy rates in first trimester pregnancy losses following IVF+/-ICSI.
methodsA retrospective cohort analysis of karyotypes of abortuses following conventional IVF (n=159) and ICSI (n=196).
results50.1% of losses were found to be cytogenetically abnormal among all patients undergoing IVF+/-ICSI. A significant increase in fetal aneuploidy rate was noted with increasing maternal age (<30 years=26.1% vs. 31 to 34 years.=38.2% vs. 35 to 39 years.=51.3% vs. >39 years.=65.9%). Aneuploidy rates were similar in the ICSI vs. conventional IVF groups (52.6% vs. 47.2% [p 0.31, RR 1.11, 95% CI 0.90, 1.38]). More sex chromosome anomalies were noted in the ICSI group.
conclusionsThe aneuploidy rate in first trimester abortuses significantly increases with increasing maternal age. ICSI was not shown to significantly increase the aneuploidy rate. However, more sex chromosome anomalies were found among pregnancies resulting from ICSI.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.