ArticleEuropean archives of psychiatry and clinical neuroscience2009
Neurological soft signs in patients with schizophrenia and their unaffected siblings: frequency and correlates in two ethnic and socioeconomic distinct populations.
Article in European archives of psychiatry and clinical neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of neurological soft signs in relatives of people with schizophrenia.BMC psychiatry · 2011Pooled it
- Neurological soft signs: Effects of trait schizotypy, psychological distress and auditory hallucination predisposition.Schizophrenia research. Cognition · 2017Article
- Cognitive control deficit in patients with first-episode schizophrenia is associated with complex deviations of early brain development.Journal of psychiatry & neuroscience : JPN · 2017Article
- Exploratory factor structure of the neurological evaluation scale in black africans with first episode schizophrenia.Data in brief · 2016Article
- Article
- Schizophrenia: a systemic disorder.Clinical schizophrenia & related psychoses · 2014Review
- Sensory and motor secondary symptoms as indicators of brain vulnerability.Journal of neurodevelopmental disorders · 2013Article
- Twin-based study of the complex interplay between childhood maltreatment, socioeconomic status and adult memory.European archives of psychiatry and clinical neuroscience · 2013Article
- Combined visual and motor disorganization in patients with schizophrenia.Frontiers in psychology · 2013Article
- Rater evaluations for psychiatric instruments and cultural differences: the positive and negative syndrome scale in China and the United States.The Journal of nervous and mental disease · 2012Article
- Perinatal complications in unaffected sisters of anorexia nervosa patients: testing a covariation model between genetic and environmental factors.European archives of psychiatry and clinical neuroscience · 2011Article
- Direct measure of the de novo mutation rate in autism and schizophrenia cohorts.American journal of human genetics · 2010Article
- Genetics and intermediate phenotypes of the schizophrenia--bipolar disorder boundary.Neuroscience and biobehavioral reviews · 2010Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have suggested that ethnicity and socioeconomic status may have an impact on the frequency and significance of neurological soft signs (NSS). However, this impact has not been adequately assessed. The objectives were to determine the NSS scores in patients with schizophrenia and their unaffected siblings and to examine the clinical and therapeutic correlates of NSS in two ethnic and socioeconomic distinct populations. Two independent replicate studies were carried out: (1) a French Caucasian sample of 69 patients with schizophrenia, 43 of their unaffected siblings and 108 control subjects; (2) a Tunisian sample of 66 patients with schizophrenia, 31 of their unaffected siblings and 60 control subjects. NSS were assessed with a multidimensional scale, previously validated in drug-naïve and treated samples of patients with schizophrenia. Both patient groups were assessed with the positive and negative syndrome scale (PANSS), the clinical global impressions (CGI) and the global assessment of functioning. NSS total scores were significantly higher in patients with schizophrenia comparatively to siblings and to controls in both studies. The two sibling groups had also higher NSS scores than controls. In addition, NSS total scores were correlated to the PANSS negative and disorganization sub-scores, to the CGI-severity of illness and to a low educational level in both studies. These studies provide a confirmation in two distinct samples of the high prevalence of NSS in patients with schizophrenia, and in their biological relatives, independently of their respective ethnic and socioeconomic origins.
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