ArticleEuropean archives of psychiatry and clinical neuroscience2009
Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population.
Article in European archives of psychiatry and clinical neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
33 citing papers in PubMed, 85 citations in OpenAlex.
- Investigation of CLOCK rs1801260 Polymorphism of Circadian Genes in Schizophrenia Patients.The Eurasian journal of medicine · 2026Article
- Reconceptualizing bipolar disorder through an integrative biological lens: synthesis, convergence, and emerging directions.Frontiers in integrative neuroscience · 2026Review
- Underlying biological mechanisms of emotion dysregulation in bipolar disorder.Frontiers in psychiatry · 2025Review
- Optimizing Chronotherapy in Psychiatric Care: The Impact of Circadian Rhythms on Medication Timing and Efficacy.Clocks & sleep · 2024Review
- Bipolar Disorder, Circadian Rhythm and Clock Genes.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Review
- A Systematic Review on the Impact of Seasonality on Severe Mental Illness Admissions: Does Seasonal Variation Affect Coercion?Healthcare (Basel, Switzerland) · 2023Review
- The trilateral interactions between mammalian target of rapamycin (mTOR) signaling, the circadian clock, and psychiatric disorders: an emerging model.Translational psychiatry · 2022Review
- Every Night and Every Morn: Effect of Variation inFrontiers in psychiatry · 2021Article
- Sleep and Circadian Medicine: Time of Day in the Neurologic Clinic.Neurologic clinics · 2019Review
- The human hypothalamus in mood disorders: The HPA axis in the center.IBRO reports · 2019Review
- Financial Stress Interacts WithFrontiers in behavioral neuroscience · 2019Article
- Circadian Variation of Migraine Attack Onset: A Review of Clinical Studies.BioMed research international · 2019Review
- Haloperidol, but not olanzapine, may affect expression ofBiological rhythm research · 2016Article
- Differences in circadian rhythmicity in CLOCK 3111T/C genetic variants in moderate obese women as assessed by thermometry, actimetry and body position.International journal of obesity (2005) · 2013Article
- Clock gene variants in mood and anxiety disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2012Review
- The role of sleep problems and circadian clock genes in childhood psychiatric disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2012Review
- The wnt pathway in mood disorders.Current neuropharmacology · 2012Article
- Case-control association study for 10 genes in patients with schizophrenia: influence of 5HTR1A variation rs10042486 on schizophrenia and response to antipsychotics.European archives of psychiatry and clinical neuroscience · 2012Article
- Circadian rhythms and mood regulation: insights from pre-clinical models.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2011Review
- Achievement and maintenance of the new impact factor 2010.European archives of psychiatry and clinical neuroscience · 2011Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently the clock genes have been reported to play some roles in neural transmitter systems, including the dopamine system, as well as to regulate circadian rhythms. Abnormalities in both of these mechanisms are thought to be involved in the pathophysiology of major mental illness such as schizophrenia and mood disorders including bipolar disorder (BP) and major depressive disorder (MDD). Recent genetic studies have reported that CLOCK, one of the clock genes, is associated with these psychiatric disorders. Therefore, we investigated the association between the six tagging SNPs in CLOCK and the risk of these psychiatric disorders in Japanese patients diagnosed with schizophrenia (733 patients), BP (149) and MDD (324), plus 795 Japanese controls. Only one association, with schizophrenia in females, was detected in the haplotype analysis (P = 0.0362). However, this significance did not remain after Bonferroni correction (P = 0.0724). No significant association was found with BP and MDD. In conclusion, we suggest that CLOCK may not play a major role in the pathophysiology of Japanese schizophrenia, BP and MDD patients. However, it will be important to replicate and confirm these findings in other independent studies using large samples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.