ArticleMolecular vision2009
Calcium-binding S100 protein expression in pterygium.
Article in Molecular vision, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Transcriptomics and network analysis highlight potential pathways in the pathogenesis of pterygium.Scientific reports · 2022Pooled it
- Prediction of cell states and key transcription factors of the human cornea through integrated single-cell omics analyses.PNAS nexus · 2025Article
- Unravelling the molecular tapestry of pterygium: insights into genes for diagnostic and therapeutic innovations.Eye (London, England) · 2024Review
- Key Genes of Immunity Associated with Pterygium and Primary Sjögren's Syndrome.International journal of molecular sciences · 2023Article
- Targeted Analysis of Tears Revealed Specific Altered Metal Homeostasis in Age-Related Macular Degeneration.Investigative ophthalmology & visual science · 2022Article
- Quantification of a panel for dry-eye protein biomarkers in tears: A comparative pilot study using standard ELISA and customized microarrays.Molecular vision · 2021Article
- Review of Biomarkers in Ocular Matrices: Challenges and Opportunities.Pharmaceutical research · 2019Review
- Changes in tear biomarker levels in keratoconus after corneal collagen crosslinking.Molecular vision · 2019Observational
- Immunophenotypic characterization of telocyte-like cells in pterygium.Molecular vision · 2018Article
- Vitamin D and vitamin D receptor in patients with ophthalmic pterygium.European journal of histochemistry : EJH · 2017Article
- Inhibitory effects ofMolecular vision · 2017Article
- Positive Association between Blood 25-Hydroxyvitamin D Levels and Pterygium after Control for Sunlight Exposure.PloS one · 2016Article
- Induction of endothelial RAGE expression in pterygium.Molecular vision · 2014Article
- Article
- S100 A and B expression in normal and inflamed human limbus.Molecular vision · 2013Article
- Cytokines in the host response to Candida vaginitis: Identifying a role for non-classical immune mediators, S100 alarmins.Cytokine · 2012Review
- Changes in gene expression in human meibomian gland dysfunction.Investigative ophthalmology & visual science · 2011Article
- Aberrant DNA methylation of matrix remodeling and cell adhesion related genes in pterygium.PloS one · 2011Article
- S100A expression in normal corneal-limbal epithelial cells and ocular surface squamous cell carcinoma tissue.Molecular vision · 2011Article
- Validation of endogenous control genes for gene expression studies on human ocular surface epithelium.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePterygium is an ocular surface disease of unknown etiology associated with epithelial and fibrovascular outgrowth from the conjunctiva onto the cornea. S100 proteins are calcium-activated signaling proteins that interact with other proteins to modulate biological functions such as cell migration, proliferation, and differentiation. The aim of this study was to investigate the presence of various S100 proteins in pterygium compared to normal conjunctiva.
methodsImmunofluorescent staining using antibodies against S100A4, S100A6, S100A8, S100A9, and S100A11 were conducted to investigate the expression and tissue distribution. S100 protein secretions and expressions were confirmed using western blot and quantitative real-time polymerase chain reaction (RT-PCR), respectively.
resultsImmunofluorescent staining demonstrated the presence of S100A4, S100A6, S100A8, S100A8, S100A9, and S100A11 in both conjunctival and pterygial epithelium. No significant difference was found in the localization and expression of S100A4. In both conjunctiva and pterygium, S100A4-positive cells were found in superficial and suprabasal layers. S100A6 expression was strong in the superficial layer of pterygium epithelium but relatively weaker in the suprabasal and superficial cells of normal conjunctiva epithelium. S100A8 and S100A9 were localized in the superficial layer of both pterygium and normal conjunctiva epithelium, with higher levels in pterygium than uninvolved conjunctiva. S100A11 was expressed in the basal cells of conjunctival epithelium but in the suprabasal layers of pterygium epithelium. Western blot and RT-PCR confirmed the presence of S100A4, S100A6, S100A8, S100A9, and S100A11 in pterygium and conjunctiva tissue.
conclusionsHigher levels of S100A6, S100A8, and S100A9 expressions were detected in the pterygium tissue relative to normal conjunctiva. In addition, a distinct alteration of localization of S100A11 expression was observed in pterygium epithelium compared to the conjunctiva. Therefore, these S100 proteins may be associated with the formation of pterygium.
Indexed as
Identifiers
19223989PMC2642841W2152209587What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.