ArticlePloS one2009
Maternal transfer and protective role of the alternative complement components in zebrafish Danio rerio.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 87 citations in OpenAlex.
- Chronic hypoxia has differential effects on constitutive and antigen-stimulated immune function in Atlantic salmon (Frontiers in immunology · 2025Article
- Discovery and Characterization of theInternational journal of molecular sciences · 2024Article
- Donepezil-Loaded Nanocarriers for the Treatment of Alzheimer's Disease: Superior Efficacy of Extracellular Vesicles Over Polymeric Nanoparticles.International journal of nanomedicine · 2024Article
- Interwoven processes in fish development: microbial community succession and immune maturation.PeerJ · 2024Review
- Teleost Fish as an Experimental Model for Vaccine Development.Methods in molecular biology (Clifton, N.J.) · 2022Article
- ELAVL1a is an immunocompetent protein that protects zebrafish embryos from bacterial infection.Communications biology · 2021Article
- The Zebrafish Perivitelline Fluid Provides Maternally-Inherited Defensive Immunity.Biomolecules · 2020Article
- Low adaptive potential for tolerance to ethynylestradiol, but also low toxicity, in a grayling population (Thymallus thymallus).BMC evolutionary biology · 2019Article
- Identification of ATP synthase α subunit as a new maternal factor capable of protecting zebrafish embryos from bacterial infection.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Interleukin-8 holds promise to serve as a molecular adjuvant in DNA vaccination model against Streptococcus iniae infection in fish.Oncotarget · 2016Article
- Molecular cloning, expression and the adjuvant effects of interleukin-8 of channel catfish (Ictalurus Punctatus) against Streptococcus iniae.Scientific reports · 2016Article
- Identification of the Zinc Finger Protein ZRANB2 as a Novel Maternal Lipopolysaccharide-binding Protein That Protects Embryos of Zebrafish against Gram-negative Bacterial Infections.The Journal of biological chemistry · 2016Article
- Mortality Caused by Bath Exposure of Zebrafish (Danio rerio) Larvae to Nervous Necrosis Virus Is Limited to the Fourth Day Postfertilization.Applied and environmental microbiology · 2015Article
- Deciphering microbial landscapes of fish eggs to mitigate emerging diseases.The ISME journal · 2014Article
- Zebrafish as a model for zoonotic aquatic pathogens.Developmental and comparative immunology · 2014Review
- Genome-wide microarray analysis of Atlantic cod (Gadus morhua) oocyte and embryo.BMC genomics · 2014Article
- Zebrafish as a novel vertebrate model to dissect enterococcal pathogenesis.Infection and immunity · 2013Article
- Microglia, Alzheimer's disease, and complement.International journal of Alzheimer's disease · 2012Article
- Phosvitin plays a critical role in the immunity of zebrafish embryos via acting as a pattern recognition receptor and an antimicrobial effector.The Journal of biological chemistry · 2011Article
- Lipovitellin is a non-self recognition receptor with opsonic activity.Marine biotechnology (New York, N.Y.) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Embryos of most fish develop externally and are exposed to an aquatic environment full of potential pathogens, whereas they have little or only limited ability to mount an efficient and protective response. How fish embryos survive pathogenic attacks remains poorly defined. Here we demonstrate that the maternal immunization of female zebrafish with formalin-killed Aeromonas hydrophila causes a significant increase in C3 and Bf contents in the mother, a corresponding rise in the offspring, and induces a remarkable increase in the hemolytic activities in both the mother and offspring. In addition, the embryos derived from the immunized mother are significantly more tolerant to A. hydrophila challenge than those from the unimmunized fish, and blocking C3 and Bf activities by injection of the antibodies against C3 and Bf into the embryos render them more susceptible to A. hydrophila. These results clearly show that the protection of zebrafish embryos against A. hydrophila can be achieved by the maternally-transferred immunity of the complement system operating via the alternative pathway. This appears to be the first report providing in vivo evidences for the protective role of the alternative complement components in the early embryos of zebrafish, paving the way for insights into the in vivo function of other maternally-transferred factors in fish.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.