ArticleAutophagy2009
Tap42-associated protein phosphatase type 2A negatively regulates induction of autophagy.
Article in Autophagy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 89 citations in OpenAlex.
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- Nutrient-dependent signaling pathways that control autophagy in yeast.FEBS letters · 2024Review
- Temperature alters the inotropic, chronotropic and proarrhythmic effects of histamine in atrial muscle preparations from humans and HNaunyn-Schmiedeberg's archives of pharmacology · 2023Article
- The Mitogen-Activated Protein Kinase Slt2 Promotes Asymmetric Cell Cycle Arrest and Reduces TORC1-Sch9 Signaling in Yeast Lacking the Protein Phosphatase Ptc1.Microbiology spectrum · 2023Article
- Effect of Amino Acids onFoods (Basel, Switzerland) · 2023Article
- TDP-43 Toxicity in Yeast Is Associated with a Reduction in Autophagy, and Deletions ofViruses · 2022Article
- Proteomic and metabolomic analysis of Nicotiana benthamiana under dark stress.FEBS open bio · 2022Article
- The Mechanism of Acrylamide-Induced Neurotoxicity: Current Status and Future Perspectives.Frontiers in nutrition · 2022Review
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- The Cell Wall Integrity Receptor Mtl1 Contributes to Articulate Autophagic Responses When Glucose Availability Is Compromised.Journal of fungi (Basel, Switzerland) · 2021Article
- Mechanisms governing autophagosome biogenesis.Nature reviews. Molecular cell biology · 2020Review
- Transcriptomic Analysis ofFrontiers in microbiology · 2020Article
- TIPRL potentiates survival of lung cancer by inducing autophagy through the eIF2α-ATF4 pathway.Cell death & disease · 2019Article
- Mitogen-activated protein kinases, Fus3 and Kss1, regulate chronological lifespan in yeast.Aging · 2017Article
- Sestrin 1 ameliorates cardiac hypertrophy via autophagy activation.Journal of cellular and molecular medicine · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Autophagy is a highly conserved degradative process in eukaryotic cells. This process plays an integral role in cellular physiology, and the levels of autophagy must be precisely controlled to prevent cellular dysfunction. The rapamycin-sensitive Tor kinase complex 1 (TORC1) has a major role in regulating the induction of autophagy; however, the regulatory mechanisms are not fully understood. Here, we find that Tap42 and protein phosphatase type 2A (PP2A) are involved in the regulation of autophagy in yeast. Temperature-sensitive mutant alleles of TAP42 revealed that autophagy was induced without inactivation of TORC1. Absence of the Tap42-interacting protein Tip41 abolished autophagy induction in the tap42 mutants, whereas overexpression of Tip41 activated autophagy. Furthermore, inactivation of PP2A stimulated autophagy and overexpression of a catalytic subunit of PP2A blocked rapamycin-induced autophagy. Our data support a model in which autophagy is negatively regulated by the Tap42-PP2A pathway.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.