ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2009
Age-related changes in subtelomeric methylation in the normal Japanese population.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Gender and telomere length: systematic review and meta-analysis.Experimental gerontology · 2014Pooled it
- Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study.GeroScience · 2021Article
- Chromosomal terminal methylation status is associated with gut microbiotic alterations.Molecular and cellular biochemistry · 2021Article
- Accelerated telomere shortening independent of LRRK2 variants in Chinese patients with Parkinson's disease.Aging · 2020Article
- Frailty is associated with the epigenetic clock but not with telomere length in a German cohort.Clinical epigenetics · 2016Observational
- Identification of telomere dysfunction in Friedreich ataxia.Molecular neurodegeneration · 2015Article
- Human leukocyte telomere length is associated with DNA methylation levels in multiple subtelomeric and imprinted loci.Scientific reports · 2014Article
- Chromatin remodeling of human subtelomeres and TERRA promoters upon cellular senescence: commonalities and differences between chromosomes.Epigenetics · 2013Article
- The Subtelomere of Short Telomeres is Hypermethylated in Alzheimer's Disease.Aging and disease · 2012Article
- Epigenetic changes in response to tai chi practice: a pilot investigation of DNA methylation marks.Evidence-based complementary and alternative medicine : eCAM · 2012Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe telomeres of somatic cells become shorter with individual aging. However, no significant change in subtelomeric methylation of somatic cells with aging has yet been reported.
methodsTelomere lengths of the peripheral blood cells of 148 normal Japanese were analyzed by Southern blotting using methylation-sensitive and -insensitive isoschizomers.
resultsWith aging, long telomeres decrease and short telomeres increase, and the contents of the telomeres with methylated subtelomere increase in long telomeres, thus leading us to postulate that telomeres with less methylated subtelomeres tend to become shortened faster.
conclusionsA telomere length distribution analysis with methylation-sensitive and -insensitive isoschizomer seems to be a useful tool to assess the subtelomeric methylation status of the somatic cell population. The subtelomeric methylation of peripheral blood cells is also indicated to be an indicator for aging-associated genomic changes.
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