ReviewThe journals of gerontology. Series A, Biological sciences and medical sciences2009
Toward a systems biology framework for understanding aging and health span.
Review in The journals of gerontology. Series A, Biological sciences and medical sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Trajectories of physiological dysregulation predicts mortality and health outcomes in a consistent manner across three populations.Mechanisms of ageing and developmentTrial
- Feeding performance, kinematics and skills change with age in a granivorous songbird.Proceedings. Biological sciences · 2025Article
- A complex systems approach to aging biology.Nature aging · 2022Review
- An Emergent Integrated Aging Process Conserved Across Primates.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Review
- An integrative modeling approach to the age-performance relationship in mammals at the cellular scale.Scientific reports · 2019Article
- A procession of metabolic alterations accompanying muscle senescence in Manduca sexta.Scientific reports · 2018Article
- Age-Related Changes in Locomotor Performance Reveal a Similar Pattern for Caenorhabditis elegans, Mus domesticus, Canis familiaris, Equus caballus, and Homo sapiens.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Multiscale entropy: A tool for understanding the complexity of postural control.Journal of sport and health science · 2016Review
- Complex systems dynamics in aging: new evidence, continuing questions.Biogerontology · 2016Review
- Article
- Extension of the mitochondria dysfunction hypothesis of metabolic syndrome to atherosclerosis with emphasis on the endocrine-disrupting chemicals and biophysical laws.Journal of diabetes investigation · 2013Review
- Rule-based cell systems model of aging using feedback loop motifs mediated by stress responses.PLoS computational biology · 2010Article
- Methusaleh's Zoo: how nature provides us with clues for extending human health span.Journal of comparative pathology · 2010Review
- Protein homeostasis and aging: taking care of proteins from the cradle to the grave.The journals of gerontology. Series A, Biological sciences and medical sciences · 2009Review
- Cell stress and aging: new emphasis on multiplex resistance mechanisms.The journals of gerontology. Series A, Biological sciences and medical sciences · 2009Review
- Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones.The journals of gerontology. Series A, Biological sciences and medical sciences · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
It is argued that aging research is at a stage where it could benefit greatly from a more intense engagement with the perspectives emphasized by systems biology and complexity science. A more integrated, systematic approach is needed if we are ever to have a fully developed, fundamental understanding of aging, longevity, and their relationship to health. A broader, deeper, more quantitative, and predictive conceptual framework can lead to theoretical approaches and realistic models that can be quantitatively confronted with data and, perhaps more importantly, stimulate novel questions and novel experiments. Integral to this is the search for underlying causal multilevel mechanisms and principles that can be quantified and developed into a serious predictive theoretical framework, providing a point of departure for framing a more integrated research agenda.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.