ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2009
Functional and morphological evidence of age-related denervation in rat laryngeal muscles.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- AChRs Degeneration at NMJ in Aging-Associated Sarcopenia-A Systematic Review.Frontiers in aging neuroscience · 2020Pooled it
- High-Speed Characterization of Vocal Fold Vibrations in Normally Cycling and Postmenopausal Women: Randomized Double-Blind Analyses.Journal of speech, language, and hearing research : JSLHR · 2021Trial
- Vocal Fold Atrophy in an Alzheimer's Disease Rat Model.The Laryngoscope · 2026Article
- Differential Expression of SERCA and Myosin Heavy Chain Isoforms in Rat Laryngeal Muscles.International archives of otorhinolaryngology · 2026Article
- Review
- Changes in vocal fold gene expression and histology after injection augmentation in a recurrent laryngeal nerve injury model.The Journal of laryngology and otology · 2024Article
- Utilizing novel recurrent laryngeal motor nerve conduction studies to characterize the aging larynx: A pilot study.Laryngoscope investigative otolaryngology · 2023Article
- An optimized method for high-quality RNA extraction from distinctive intrinsic laryngeal muscles in the rat model.Scientific reports · 2022Article
- Biological and Acoustic Sex Differences in Rat Ultrasonic Vocalization.Brain sciences · 2021Review
- Preparation of the Rat Vocal Fold for Neuromuscular Analyses.Journal of visualized experiments : JoVE · 2020Article
- A Tutorial of the Effects of Sex Hormones on Laryngeal Senescence and Neuromuscular Response to Exercise.Journal of speech, language, and hearing research : JSLHR · 2019Review
- An Overview of Neuromuscular Junction Aging Findings in Human and Animal Studies.Current aging science · 2019Review
- Social isolation alters ultrasonic vocalizations but not thyroarytenoid neuromuscular junctions in old rats.The Laryngoscope · 2019Article
- Hypothalamic Sirt1 protects terminal Schwann cells and neuromuscular junctions from age-related morphological changes.Aging cell · 2018Article
- Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass.Redox biology · 2018Article
- Profile of sugammadex for reversal of neuromuscular blockade in the elderly: current perspectives.Clinical interventions in aging · 2018Review
- Subcutaneous Neurotrophin 4 Infusion Using Osmotic Pumps or Direct Muscular Injection Enhances Aging Rat Laryngeal Muscles.Journal of visualized experiments : JoVE · 2017Article
- Enhancement of aging rat laryngeal muscles with endogenous growth factor treatment.Physiological reports · 2016Article
- The effects of treadmill running on aging laryngeal muscle structure.The Laryngoscope · 2016Article
- Vocal training mitigates age-related changes within the vocal mechanism in old rats.The journals of gerontology. Series A, Biological sciences and medical sciences · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Laryngeal muscle dysfunction compromises voice, swallowing, and airway protection in elderly adults. Laryngeal muscles and their motor neurons and their motor neurons communicate via the neuromuscular junction (NMJ). We tested the hypothesis that aging disrupts NMJ organization and function in the laryngeal thyroarytenoid (TA) and posterior cricoarytenoid (PCA) muscles We determined NMJ density and size and acetylcholine receptor (AChR) subunit mRNAs in TA and PCA muscles from 6-, 18-, and 30- month old-rats. NMJ function was determined with tubocurarine (TC) and contractions during nerve and muscle stimulation. NMJ size, abundance, and clustering decreased in 30-month TA and PCA muscles. AChRe mTNA and protein increased with age in both muscles. AChRg mRNA increased with age in both muscles while protein content increased in TA only. Aging PCA and TA were more sensitive to TC, demonstrating functional evidence of denervation. These results demonstrate that NMJs become smaller and less abundant in aging TA and PCA muscles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.