ArticleProceedings of the National Academy of Sciences of the United States of America2009
GABA expression in the mammalian taste bud functions as a route of inhibitory cell-to-cell communication.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 51 citations in OpenAlex.
- Caffeine, MitoQ, and GABA Prophylaxis of Mitochondrial Dysfunction Induced in Human Pulmonary Cells by Normobaric-Hyperoxia and Hyperbaric-Hyperoxia.Oxidative medicine and cellular longevity · 2025Article
- The role of GABA in modulation of taste signaling within the taste bud.Pflugers Archiv : European journal of physiology · 2024Article
- Delving into the reducing effects of the GABAAlcohol (Fayetteville, N.Y.) · 2023Article
- The Role of ATP and Purinergic Receptors in Taste Signaling.Handbook of experimental pharmacology · 2022Review
- Is there a role for GABA in peripheral taste processing.Current opinion in physiology · 2021Article
- Patterns of allele frequency differences among domestic cat breeds assessed by a 63K SNP array.PloS one · 2021Article
- Optogenetic Activation of Type III Taste Cells Modulates Taste Responses.Chemical senses · 2020Article
- Substance P as a putative efferent transmitter mediates GABAergic inhibition in mouse taste buds.British journal of pharmacology · 2018Article
- Calcitonin Gene-Related Peptide Reduces Taste-Evoked ATP Secretion from Mouse Taste Buds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Dual mechanism for bitter avoidance in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Taste perception, associated hormonal modulation, and nutrient intake.Nutrition reviews · 2015Review
- L-Amino Acids Elicit Diverse Response Patterns in Taste Sensory Cells: A Role for Multiple Receptors.PloS one · 2015Article
- GABAAα1 and GABAAρ1 subunits are expressed in cultured human RPE cells and GABAA receptor agents modify the intracellular calcium concentration.Molecular vision · 2015Article
- Amino acid derivatives as bitter taste receptor (T2R) blockers.The Journal of biological chemistry · 2014Article
- Interleukin-10 is produced by a specific subset of taste receptor cells and critical for maintaining structural integrity of mouse taste buds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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- A taste for ATP: neurotransmission in taste buds.Frontiers in cellular neuroscience · 2013Review
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- Peptide regulators of peripheral taste function.Seminars in cell & developmental biology · 2013Review
- Acetylcholine is released from taste cells, enhancing taste signalling.The Journal of physiology · 2012Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Recent advances have underscored cell-to-cell communication as an important component of the operation of taste buds with individual taste receptor cells (TRCs) communicating with one another by means of a number of neurotransmitters and neuropeptides, although functional roles are not yet understood. Here, we characterize the presence, distribution pattern, phenotype, and functional consequences of a previously undescribed inhibitory route within the taste bud mediated by the classic neurotransmitter GABA and its receptors. By using immunocytochemistry, subsets of TRCs within rat taste buds were identified as expressing GABA, and its synthetic enzyme glutamate decarboxylase (GAD). GAD expression was verified with Western blotting. Immunofluorescent studies revealed complex coexpression patterns of GAD with the TRC protein markers gustducin, neural cell adhesion molecule, protein gene product 9.5, and synaptosomal-associated protein of 25 kDa that collectively outline hardwired signaling pathways of GABAergic TRCs. RT-PCR and immunocytochemistry demonstrated that both GABA(A) and GABA(B) receptors are expressed in the taste bud. The later was observed in a subset TRCs paracrine to GAD-expressing TRCs. Physiological effects of GABA were examined by patch clamp recordings. GABA and the GABA(A) agonists muscimol and isoguvacine enhanced isolated chloride currents in a dose-dependent manner. Also, GABA and the GABA(B) agonist baclofen both elicited increases of the inwardly rectifying potassium currents that could be blocked by the GABA(B) receptor antagonist CGP 35348 and the G protein blocker GDP-betaS. Collectively, these data suggest that GABAergic TRCs are able to shape the final chemosensory output of the bud by means of processes of cell-to-cell modulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.