ArticleInfection and immunity2009
Concurrent Helicobacter bilis infection in C57BL/6 mice attenuates proinflammatory H. pylori-induced gastric pathology.
Article in Infection and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 60 citations in OpenAlex.
- Article
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- Role of the Gastric Microbiome in Gastric Cancer: From Carcinogenesis to Treatment.Frontiers in microbiology · 2021Review
- Male-Dependent Promotion of Colitis in 129International journal of molecular sciences · 2020Article
- Gastroprotective effect of phytoncide extract from Pinus koraiensis pinecone in Helicobacter pylori infection.Scientific reports · 2020Article
- Effects of Colonization of Gnotobiotic Swiss Webster Mice withComparative medicine · 2020Article
- Helicobacter pylori-infected C57BL/6 mice with different gastrointestinal microbiota have contrasting gastric pathology, microbial and host immune responses.Scientific reports · 2018Article
- The gastric microbiome, its interaction with Helicobacter pylori, and its potential role in the progression to stomach cancer.PLoS pathogens · 2017Review
- Article
- Novel Helicobacter species H.japonicum isolated from laboratory mice from Japan induces typhlocolitis and lower bowel carcinoma in C57BL/129 IL10-/- mice.Carcinogenesis · 2016Article
- Different gastric microbiota compositions in two human populations with high and low gastric cancer risk in Colombia.Scientific reports · 2016Article
- Pathobiology of Helicobacter pylori-Induced Gastric Cancer.Gastroenterology · 2016Review
- Helicobacter cinaedi induced typhlocolitis in Rag-2-deficient mice.Helicobacter · 2015Article
- Association of seropositivity to Helicobacter species and biliary tract cancer in the ATBC study.Hepatology (Baltimore, Md.) · 2014Article
- Helicobacter pylori infection and inflammatory bowel disease: is there a link?World journal of gastroenterology · 2014Review
- Gastrointestinal malignancy and the microbiome.Gastroenterology · 2014Review
- Helminth co-infection in Helicobacter pylori infected INS-GAS mice attenuates gastric premalignant lesions of epithelial dysplasia and glandular atrophy and preserves colonization resistance of the stomach to lower bowel microbiota.Microbes and infection · 2014Article
- Dietary factors modulate Helicobacter-associated gastric cancer in rodent models.Toxicologic pathology · 2014Article
- The degree of Helicobacter pylori-triggered inflammation is manipulated by preinfection host microbiota.Infection and immunity · 2013Article
- Mouse models of gastric cancer.Cancers · 2013Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Because coinfections can alter helicobacter gastritis, we investigated whether enterohepatic Helicobacter bilis modulates Helicobacter pylori gastritis in C57BL/6 mice. Thirty mice per group were sham dosed, H. bilis or H. pylori infected, or H. bilis infected followed in 2 weeks by H. pylori and then evaluated at 6 and 11 months postinfection (mpi) for gastritis and premalignant lesions. Compared to H. pylori-infected mice, H. bilis/H. pylori-infected mice at 6 and 11 mpi had less severe gastritis, atrophy, mucous metaplasia and hyperplasia (P < 0.01) and, additionally, at 11 mpi, less severe intestinal metaplasia and dysplasia (P < 0.05). H. bilis/H. pylori-infected mice at 11 mpi exhibited less Ki67 labeling of proliferating epithelial cells, reduced numbers of FoxP3(+) T-regulatory (T(REG)) cells, and lower FoxP3(+) mRNA levels than did H. pylori-infected mice (P < 0.05). Proinflammatory interleukin-1beta (IL-1beta), gamma interferon, and tumor necrosis factor alpha mRNA levels were attenuated in H. bilis/H. pylori-infected mice at 6 and 11 mpi (P < 0.01), although anti-inflammatory IL-10, IL-13, and transforming growth factor beta1 mRNA levels were not consistently impacted by H. bilis coinfection. Decreased pathology in H. bilis/H. pylori-infected mice correlated with higher gastric H. pylori colonization at 6 mpi (P < 0.001) and lower Th1-associated immunoglobulin G2c responses to H. pylori at 6 and 10 mpi (P < 0.05). We hypothesized that reduced pathology in H. bilis/H. pylori-infected mice was due to H. bilis-primed T(REG) cells in the lower bowel that migrated to the gastric compartment and inhibited Th1 responses to subsequent H. pylori infection. Thus, H. pylori-induced gastric lesions may vary in mouse models of unknown enteric helicobacter infection status and, importantly, variable sequelae to human H. pylori infection, particularly in developing countries, may occur where coinfection with lower bowel helicobacters and H. pylori may be common.
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