ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2009
Quantification of tryptophan transport and metabolism in lung tumors using PET.
Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Quantitative PET imaging of tryptophan accumulation in gliomas and remote cortex: correlation with tumor proliferative activity.Clinical nuclear medicine · 2012Trial
- Radiopharmaceuticals and their applications in medicine.Signal transduction and targeted therapy · 2025Review
- Tryptophan Kynurenine Pathway-Based Imaging Agents for Brain Disorders and Oncology-From Bench to Bedside.Biomolecules · 2025Review
- Metabolomic differentiation of benign vs malignant pulmonary nodules with high specificity via high-resolution mass spectrometry analysis of patient sera.Nature communications · 2023Article
- Immunometabolic Network Interactions of the Kynurenine Pathway in Cutaneous Malignant Melanoma.Frontiers in oncology · 2020Article
- Evaluation of L-1-[Molecular imaging and biology · 2019Article
- Tracers for non-invasive radionuclide imaging of immune checkpoint expression in cancer.EJNMMI radiopharmacy and chemistry · 2019Review
- Metabolic signatures of four major histological types of lung cancer cells.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- Evaluation of radiofluorinated carboximidamides as potential IDO-targeted PET tracers for cancer imaging.Oncotarget · 2017Article
- Assessment of Tryptophan Uptake and Kinetics Using 1-(2-18F-Fluoroethyl)-l-Tryptophan and α-11C-Methyl-l-Tryptophan PET Imaging in Mice Implanted with Patient-Derived Brain Tumor Xenografts.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2017Article
- Imaging cerebral tryptophan metabolism in brain tumor-associated depression.EJNMMI research · 2015Article
- Molecular imaging correlates of tryptophan metabolism via the kynurenine pathway in human meningiomas.Neuro-oncology · 2015Article
- Synthesis of [(18) F] 4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide (IDO5L): a novel potential PET probe for imaging of IDO1 expression.Journal of labelled compounds & radiopharmaceuticals · 2015Article
- 1-butyltryptophan inhibits cell proliferation, migration, and invasion through the Akt pathway in human gastric cancer cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Comparison of amino acid positron emission tomographic radiotracers for molecular imaging of primary and metastatic brain tumors.Molecular imaging · 2014Review
- Indoleamine 2,3-dioxygenase activity and clinical outcome following induction chemotherapy and concurrent chemoradiation in Stage III non-small cell lung cancer.Oncoimmunology · 2013Article
- Tryptophan metabolism in breast cancers: molecular imaging and immunohistochemistry studies.Nuclear medicine and biology · 2012Article
- The Potential Benefit by Application of Kinetic Analysis of PET in the Clinical Oncology.ISRN oncology · 2012Article
- Volume-normalized uptake rates with robust transportability from PET dual-time and Patlak analyses.Molecular imaging and biology · 2010Article
- Molecular imaging and targeted therapies.Biochemical pharmacology · 2010Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledAbnormal tryptophan metabolism catalyzed by indoleamine 2,3-dioxygenase may play a prominent role in tumor immunoresistance in many tumor types, including lung tumors. The goal of this study was to evaluate the in vivo kinetics of alpha-(11)C-methyl-l-tryptophan (AMT), a PET tracer for tryptophan metabolism, in human lung tumors.
methodsTracer transport and metabolic rates were evaluated in 18 lesions of 10 patients using dynamic PET/CT with AMT. The kinetic values were compared between tumors and unaffected lung tissue, tested against a simplified analytic approach requiring no arterial blood sampling, and correlated with standardized uptake values (SUVs) obtained from (18)F-FDG PET/CT scans.
resultsMost non-small cell lung cancers (NSCLCs) showed prolonged retention of AMT, but 3 other lesions (2 benign lesions and a rectal cancer metastasis) and unaffected lung tissue showed no such retention. Transport and metabolic rates of AMT were substantially higher in NSCLCs than in the other tumors and unaffected lung tissue. A simplified analytic approach provided an excellent estimate of transport rates but only suboptimal approximation of tryptophan metabolic rates. (18)F-FDG SUVs showed a positive correlation with AMT uptake, suggesting higher tryptophan transport and metabolism in tumors with higher proliferation rates.
conclusionProlonged retention of AMT in NSCLCs suggests high metabolic rates of tryptophan in these tumors. AMT PET/CT may be a clinically useful molecular imaging method for personalized cancer treatment by identifying and monitoring patients who have increased tumor tryptophan metabolism and are potentially sensitive to immunopharmacotherapy with indoleamine 2,3-dioxygenase inhibitors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.