ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2009
Use of human vascular tissue microarrays for measurement of advanced glycation endproducts.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Model studies of advanced glycation end product modification of heterograft biomaterials: The effects of in vitro glucose, glyoxal, and serum albumin on collagen structure and mechanical properties.Acta biomaterialia · 2021Article
- Article
- Plasma Levels of Advanced Glycation End Products Are Related to the Clinical Presentation and Angiographic Severity of Symptomatic Lower Extremity Peripheral Arterial Disease.The International journal of angiology : official publication of the International College of Angiology, Inc · 2016Article
- Advanced Glycation End Products Evolution after Pancreas-Kidney Transplantation: Plasmatic and Cutaneous Assessments.Oxidative medicine and cellular longevity · 2016Article
- Large elastic artery stiffness with aging: novel translational mechanisms and interventions.Aging and disease · 2013Article
- [Update on diabetic macroangiopathy].Der Pathologe · 2012Review
- Review
- Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation.PLoS biology · 2012Article
- Quantitative analysis of p53 expression in human normal and cancer tissue microarray with global normalization method.International journal of clinical and experimental pathology · 2011Article
- Sulfiredoxin-Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- A comprehensive histopathological evaluation of vascular medial fibrosis: insights into the pathophysiology of arterial stiffening.Atherosclerosis · 2010Article
- Immunohistochemistry in diagnostic surgical pathology: contributions of protein life-cycle, use of evidence-based methods and data normalization on interpretation of immunohistochemical stains.International journal of clinical and experimental pathology · 2009Review
- Glomerular protein levels of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 are lower in diabetic subjects.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Advanced glycation endproducts (AGEs) are present in the vasculature and are associated with vascular disease. We determined levels of AGEs in eight distinct adult vascular tissues using tissue microarray (TMA) technology and associated these levels with clinical characteristics. Medium-to-large caliber blood vessels were harvested from 100 adult autopsies to create 17 TMAs. AGE levels were evaluated by IHC using a polyclonal anti-AGE antibody on over 700 unique blood vessels. Slides were digitally scanned, and quantitative analysis was performed using a color deconvolution image analysis technique. Medial AGE staining was strongly correlated between all eight blood vessels. In the media, AGE staining levels were significantly higher at older ages (p=0.009), in white subjects (p<0.001) and with longer postmortem interval (PMI; p<0.0001). These associations remained significant after simultaneous adjustment for age, race/ethnicity, PMI, and diabetes status. Diabetes was associated with elevated AGE levels but only after adjustment for confounding by clinical variables including race/ethnicity, hypertension, and kidney function. This extensive vascular study shows that AGE accumulation in the macrovasculature is a global process affecting atherosclerosis-prone and -resistant vessels. It also suggests ethnicity has a previously undescribed role in vascular tissue AGE levels. This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials.
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Registered trials
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