Evidence map›Paper›PMID 19222848›Full record

ArticleScandinavian journal of trauma, resuscitation and emergency medicine2009

Successful use of inhaled nitric oxide to decrease intracranial pressure in a patient with severe traumatic brain injury complicated by acute respiratory distress syndrome: a role for an anti-inflammatory mechanism?

Thomas J Papadimos, Azedine Medhkour, Sooraj Yermal

Registry-linked trialOpen access · goldAbstract readCase Reports
In one paragraph

Article in Scandinavian journal of trauma, resuscitation and emergency medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03260569 (Respiratory Mechanics Following Brain Injury), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03260569 phase3completednot on this mapstarted 2018, after this paper: background citation

Respiratory Mechanics Following Brain Injury: The Role of Inhaled Nitric Oxide

TypeinterventionalSponsorUniversity of CincinnatiRan2018 to 2023Enrolled13ConditionsTraumatic Brain InjuryArmsInhaled Nitric Oxide, Placebo
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Nitric oxide and traumatic brain injury.Medical gas research · 2027
    Review
  3. Article
  4. Article
  5. Review
  6. The role of inhaled nitric oxide beyond ARDS.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2014
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Thomas J PapadimosDepartment of Anesthesiology, College of Medicine, University of Toledo, Toledo, OH 43614, USA. thomas.papadimos@utoledo.edu
Azedine Medhkour
Sooraj Yermal
University of Toledo · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Use of inhaled nitric oxide in humans with traumatic brain injury and acute respiratory distress syndrome has twice previously been reported to be beneficial. Here we report a third case. We propose that INO may decrease the inflammatory response in patients with increased intracranial pressure caused by traumatic brain injury accompanied by acute respiratory distress syndrome thereby contributing to improved outcomes.

Indexed as

Accidents, TrafficAdultAnti-Inflammatory AgentsBrain InjuriesFree Radical ScavengersHumansIntracranial PressureMaleNitric OxideRespiratory Distress SyndromeAnti-Inflammatory AgentsFree Radical ScavengersNitric Oxide

Identifiers

PMID19222848
PMCPMC2657771
OpenAlexW2075113783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.