ArticleCell stress & chaperones2009
Hyperthermia in the febrile range induces HSP72 expression proportional to exposure temperature but not to HSF-1 DNA-binding activity in human lung epithelial A549 cells.
Article in Cell stress & chaperones, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Extreme temperatures modulate gene expression in the airway epithelium of the lungs in mice and asthma patients.Frontiers in medicine · 2025Article
- Hyperthermia increases HSP production in human PDMCs by stimulating ROS formation, p38 MAPK and Akt signaling, and increasing HSF1 activity.Stem cell research & therapy · 2022Article
- The functions and regulation of heat shock proteins; key orchestrators of proteostasis and the heat shock response.Archives of toxicology · 2021Review
- Differential correlations between changes to glutathione redox state, protein ubiquitination, and stress-inducible HSPA chaperone expression after different types of oxidative stress.Cell stress & chaperones · 2018Article
- Exposure to febrile-range hyperthermia potentiates Wnt signalling and epithelial-mesenchymal transition gene expression in lung epithelium.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2018Article
- Activation of heat shock response augments fibroblast growth factor-1 expression in wounded lung epithelium.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Self-harm to preferentially harm the pathogens within: non-specific stressors in innate immunity.Proceedings. Biological sciences · 2016Review
- The interactive association between heat shock factor 1 and heat shock proteins in primary myocardial cells subjected to heat stress.International journal of molecular medicine · 2016Article
- Shifts in temperature within the physiologic range modify strand-specific expression of select human microRNAs.RNA (New York, N.Y.) · 2015Article
- Fever and the thermal regulation of immunity: the immune system feels the heat.Nature reviews. Immunology · 2015Review
- Antipyretic therapy in critically ill patients with sepsis: an interaction with body temperature.PloS one · 2015Article
- Article
- Estimates of exposure to cold before death from immunohistochemical expression patterns of HSP70 in glomerular podocytes.International journal of legal medicine · 2013Article
- Toll-like receptor agonists and febrile range hyperthermia synergize to induce heat shock protein 70 expression and extracellular release.The Journal of biological chemistry · 2013Article
- Febrile-range hyperthermia modifies endothelial and neutrophilic functions to promote extravasation.American journal of respiratory cell and molecular biology · 2012Article
- Mexiletine differentially restores the trafficking defects caused by two brugada syndrome mutations.Frontiers in pharmacology · 2012Article
- Unmasking a temperature-dependent effect of the P. anserina i-AAA protease on aging and development.Cell cycle (Georgetown, Tex.) · 2011Article
- Distinct, gene-specific effect of heat shock on heat shock factor-1 recruitment and gene expression of CXC chemokine genes.Cytokine · 2011Article
- Rapid changes in heat-shock cognate 70 levels, heat-shock cognate phosphorylation state, heat-shock transcription factor, and metal transcription factor activity levels in response to heavy metal exposure during sea urchin embryonic development.Ecotoxicology (London, England) · 2011Article
- Prostaglandin E2 potentiates heat shock-induced heat shock protein 72 expression in A549 cells.Prostaglandins & other lipid mediators · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Expression of heat shock proteins (HSPs) is classically activated at temperatures above the physiologic range (>or=42 degrees C) via activation of the stress-activated transcription factor, heat shock factor-1 (HSF-1). Several studies suggest that less extreme hyperthermia, especially within the febrile range, as occurs during fever and exertional/environmental hyperthemia, can also activate HSF-1 and enhance HSP expression. We compared HSP72 protein and mRNA expression in human A549 lung epithelial cells continuously exposed to 38.5 degrees C, 39.5 degrees C, or 41 degrees C or exposed to a classic heat shock (42 degrees C for 2 h). We found that expression of HSP72 protein and mRNA increased linearly as incubation temperature was increased from 37 degrees C to 41 degrees C, but increased abruptly when the incubation temperature was raised to 42 degrees C. A similar response in luciferase activity was observed using A549 cells stably transfected with an HSF-1-responsive luciferase reporter plasmid. However, activation of intranuclear HSF-1 DNA-binding activity was comparable at 38.5 degrees C, 39.5 degrees C, and 41 degrees C and only modestly greater at 42 degrees C but the mobility of HSF1 protein on a denaturing gel was altered with increasing exposure temperature and was distinctly different at 42 degrees C. These findings indicate that the proportional changes in HSF-1-dependent HSP72 expression at febrile-range temperatures are dependent upon exposure time and temperature but not on the degree of HSF-1 DNA-binding activity. Instead, HSF-1-mediated HSP expression following hyperthermia and heat shock appears to be mediated, in addition to HSF-1 activation, by posttranslational modifications of HSF-1 protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.