ArticleIntensive care medicine2009
Effects of frequency and inspiratory plateau pressure during recruitment manoeuvres on lung and distal organs in acute lung injury.
Article in Intensive care medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 58 citations in OpenAlex.
- How sighing regulates pulmonary surfactant structure and its role in breathing mechanics.Science advances · 2025Article
- n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout.International journal of molecular sciences · 2023Article
- Management of refractory hypoxemia using recruitment maneuvers and rescue therapies: A comprehensive review.Frontiers in veterinary science · 2023Review
- Effects of airway pressure release ventilation on multi-organ injuries in severe acute respiratory distress syndrome pig models.BMC pulmonary medicine · 2022Article
- Ventilator-induced Lung Injury.Clinics in chest medicine · 2016Review
- Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria.Intensive care medicine · 2016Observational
- Understanding recruitment maneuvers.Intensive care medicine · 2016Review
- Mild loss of lung aeration augments stretch in healthy lung regions.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Pediatric Acute Respiratory Distress Syndrome: Fibrosis versus Repair.Frontiers in pediatrics · 2016Review
- Recruitment maneuvers in acute respiratory distress syndrome: The safe way is the best way.World journal of critical care medicine · 2015Review
- Ventilator-Induced Lung Injury (VILI) in Acute Respiratory Distress Syndrome (ARDS): Volutrauma and Molecular Effects.The open respiratory medicine journal · 2015Article
- Effects of sigh during pressure control and pressure support ventilation in pulmonary and extrapulmonary mild acute lung injury.Critical care (London, England) · 2014Article
- Mechanical ventilation-associated lung fibrosis in acute respiratory distress syndrome: a significant contributor to poor outcome.Anesthesiology · 2014Review
- Effects of pulmonary acid aspiration on the lungs and extra-pulmonary organs: a randomized study in pigs.Critical care (London, England) · 2012Article
- Effects of different tidal volumes in pulmonary and extrapulmonary lung injury with or without intraabdominal hypertension.Intensive care medicine · 2012Article
- Efficacy and safety of recruitment maneuvers in acute respiratory distress syndrome.Annals of intensive care · 2011Article
- Assisted ventilation modes reduce the expression of lung inflammatory and fibrogenic mediators in a model of mild acute lung injury.Intensive care medicine · 2010Article
- Year in review in Intensive Care Medicine 2009: II. Neurology, cardiovascular, experimental, pharmacology and sedation, communication and teaching.Intensive care medicine · 2010Article
- Hypervolemia induces and potentiates lung damage after recruitment maneuver in a model of sepsis-induced acute lung injury.Critical care (London, England) · 2010Article
- New and conventional strategies for lung recruitment in acute respiratory distress syndrome.Critical care (London, England) · 2010Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the effects of frequency and inspiratory plateau pressure (Pplat) during recruitment manoeuvres (RMs) on lung and distal organs in acute lung injury (ALI).
methodsWe studied paraquat-induced ALI rats. At 24 h, rats were anesthetized and RMs were applied using continuous positive airway pressure (CPAP, 40 cmH(2)O/40 s) or three-different sigh strategies: (a) 180 sighs/h and Pplat = 40 cmH(2)O (S180/40), (b) 10 sighs/h and Pplat = 40 cmH(2)O (S10/40), and (c) 10 sighs/h and Pplat = 20 cmH(2)O (S10/20).
resultsS180/40 yielded alveolar hyperinflation and increased lung and kidney epithelial cell apoptosis as well as type III procollagen (PCIII) mRNA expression. S10/40 resulted in a reduction in epithelial cell apoptosis and PCIII expression. Static elastance and alveolar collapse were higher in S10/20 than S10/40.
conclusionsThe reduction in sigh frequency led to a protective effect on lung and distal organs, while the combination with reduced Pplat worsened lung mechanics and histology.
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