Evidence map›Paper›PMID 19221713›Full record

ArticleIntensive care medicine2009

Cecal ligation and puncture induced sepsis impairs host defense against Enterococcus faecium peritonitis.

Masja Leendertse, Rob J Willems, Ida A Giebelen, Sandrine Florquin, Petra S van den Pangaart, Marc J Bonten, Tom van der Poll

Open access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in Intensive care medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Masja LeendertseCenter for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands. m.leendertse@amc.uva.nl
Rob J Willems
Ida A Giebelen
Sandrine Florquin
Petra S van den Pangaart
Marc J Bonten
Tom van der Poll
Academic Medical Center · NLUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMultiresistant and vancomycin resistant Enterococcus faecium (VRE) can cause serious infections in hospitalized patients with various co-morbid diseases. We investigated the course of VRE peritonitis after cecal ligation and puncture (CLP)-induced sepsis and compared this to sham operated mice.

methodsMice were subjected to CLP or sham surgery. Forty-eight hours thereafter four groups were created by subjecting mice to peritoneal injection of either VRE or saline.

resultsMice infected with VRE after CLP were severely impaired in eliminating VRE from the peritoneal cavity and distant body sites. These mice failed to mount an early inflammatory response at the primary site of VRE infection. VRE superinfection did not influence CLP-induced organ damage or polymicrobial bacterial loads.

conclusionsSublethal polymicrobial sepsis greatly facilitates infection and dissemination of VRE. VRE does not influence the course of CLP-induced sepsis.

Indexed as

Enterococcus faeciumAnimalsCecumChemokine CCL2Enzyme-Linked Immunosorbent AssayFemaleGram-Positive Bacterial InfectionsInterferon-gammaInterleukinsLigationMicePeritonitisPuncturesRatsRats, Sprague-DawleySepsisCcl2 protein, ratChemokine CCL2Interferon-gammaInterleukinsTumor Necrosis Factor-alpha

Identifiers

PMID19221713
OpenAlexW2128441942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.