ArticleCell cycle (Georgetown, Tex.)2009
Upregulation of Nox4 in the aging vasculature and its association with smooth muscle cell polyploidy.
Article in Cell cycle (Georgetown, Tex.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 63 citations in OpenAlex.
- Vascular aging and cardiovascular disease: pathophysiology and measurement in the coronary arteries.Frontiers in cardiovascular medicine · 2023Review
- MiRNA-99a alleviates inflammation and oxidative stress in lipopolysaccharide-stimulated PC-12 cells and rats post spinal cord injury.Bioengineered · 2022Article
- Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies.Antioxidants (Basel, Switzerland) · 2021Review
- Aging-Induced Impairment of Vascular Function: Mitochondrial Redox Contributions and Physiological/Clinical Implications.Antioxidants & redox signaling · 2021Review
- Dynamic Crosstalk between Vascular Smooth Muscle Cells and the Aged Extracellular Matrix.International journal of molecular sciences · 2021Review
- Inhibition of NADPH oxidase alleviates germ cell apoptosis and ER stress during testicular ischemia reperfusion injury.Saudi journal of biological sciences · 2020Article
- Sphingosine Kinase 1/S1P Signaling Contributes to Pulmonary Fibrosis by Activating Hippo/YAP Pathway and Mitochondrial Reactive Oxygen Species in Lung Fibroblasts.International journal of molecular sciences · 2020Article
- Potential Role of Cellular Senescence in Asthma.Frontiers in cell and developmental biology · 2020Review
- Senescent cells: a therapeutic target for cardiovascular disease.The Journal of clinical investigation · 2018Review
- Hypoxia/reperfusion predisposes to atherosclerosis.PloS one · 2018Article
- Proinflammatory Arterial Stiffness Syndrome: A Signature of Large Arterial Aging.Journal of vascular research · 2018Review
- Aurora A Kinase Inhibitor AKI603 Induces Cellular Senescence in Chronic Myeloid Leukemia Cells Harboring T315I Mutation.Scientific reports · 2016Article
- Article
- Redox mechanisms in age-related lung fibrosis.Redox biology · 2016Review
- Downregulating p22phox ameliorates inflammatory response in Angiotensin II-induced oxidative stress by regulating MAPK and NF-κB pathways in ARPE-19 cells.Scientific reports · 2015Article
- Age-associated pro-inflammatory remodeling and functional phenotype in the heart and large arteries.Journal of molecular and cellular cardiology · 2015Review
- Tempol intake improves inflammatory status in aged mice.Journal of clinical biochemistry and nutrition · 2014Article
- Proinflammation: the key to arterial aging.Trends in endocrinology and metabolism: TEM · 2014Review
- Proinflammation of aging central arteries: a mini-review.Gerontology · 2014Review
- ROS-mediated platelet generation: a microenvironment-dependent manner for megakaryocyte proliferation, differentiation, and maturation.Cell death & disease · 2013Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Our recent reports indicated that polyploidization of aortic vascular smooth muscle cells (VSMC) serves as a biomarker for aging, and that the polyploid state is linked to a higher incidence of senescence in vivo. Here, we found that NADPH oxidase 4 (Nox4) expression is augmented in VSMC from aortas of old rats and that Nox4 levels are increased in polyploid VSMC in comparison to diploid cells in vivo. Seeking to determine if Nox4 upregulation plays a causal role in the accumulation of polyploid cells, we performed ploidy analysis on primary VSMC transduced with Nox4 adenovirus. We observed a consistent accumulation of polyploid cells and a concomitant decrease in the percentage of diploid cells in Nox4 overexpressing cells in comparison to controls or to cells overexpressing dominant negative Nox4. Further exploration of this phenomenon in VSMC cultures identified a Nox4-induced decrease in the chromosome passenger protein, survivin, whose absence and mislocalization during polyploidization was previously shown to induce VSMC polyploidy. Taken together, our study is the first to show increased Nox4 levels in VSMC during aging, and to demonstrate its role in induction of polyploidy in this lineage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.