Trial reportNeurology2009
ACE D/I polymorphism, migraine, and cardiovascular disease in women.
Trial report in Neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- A Comprehensive Investigation into the Association Between Mthfr C677t, A1298c, and Ace I/D Variants and Risk of Migraine: an Updated Meta-Analysis of Genetic Association Studies with Trial Sequential Analysis and Meta-Regression.Journal of molecular neuroscience : MN · 2023Pooled it
- Candidate Gene Association Studies of Anthracycline-induced Cardiotoxicity: A Systematic Review and Meta-analysis.Scientific reports · 2017Pooled it
- Guideline
- Preventive pharmacologic treatments for episodic migraine in adults.Journal of general internal medicine · 2013Pooled it
- MTHFR 677C>T and ACE D/I polymorphisms in migraine: a systematic review and meta-analysis.Headache · 2010Pooled it
- Angiotensin-Converting Enzyme (ACE) Insertion/Deletion (I/D) Polymorphism and Migraine Susceptibility and Phenotypes: A Clinical-Genetic Study in a United Arab Emirates (UAE) Cohort.Journal of clinical medicine · 2026Article
- Sirtuins Contribute to the Migraine-Stroke Connection.International journal of molecular sciences · 2025Review
- Association of MTHFR gene polymorphisms with migraine in North Indian population.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- Comorbidity of Migraine.Noro psikiyatri arsivi · 2013Review
- Genetic determinants of cardiovascular events among women with migraine: a genome-wide association study.PloS one · 2011Article
- Migraine and risk of haemorrhagic stroke in women: prospective cohort study.BMJ (Clinical research ed.) · 2010Article
- Migraine, migraine features, and cardiovascular disease.Headache · 2010Article
- MTHFR 677C->T and ACE D/I polymorphisms and migraine attack frequency in women.Cephalalgia : an international journal of headache · 2010Article
- Implications of the angiotensin converting enzyme gene insertion/deletion polymorphism in health and disease: a snapshot review.International journal of molecular epidemiology and genetics · 2010Article
- Comorbidities of migraine.Frontiers in neurology · 2010Article
- Platelet dysfunction and stroke in the female migraineur.Current pain and headache reports · 2009Review
- Molecular genetics of migraine.Human genetics · 2009Review
- Newest aspects on the association between migraine and cardiovascular disease: the role of modifying factors.Current pain and headache reports · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundInterrelationships among the ACE deletion/insertion (D/I) polymorphism (rs1799752), migraine, and cardiovascular disease (CVD) are biologically plausible but remain controversial.
methodsAssociation study among 25,000 white US women, participating in the Women's Health Study, with information on the ACE D/I polymorphism. Migraine and migraine aura status were self-reported. Incident CVD events were confirmed after medical record review. We used logistic regression to investigate the genotype-migraine association and proportional hazards models to evaluate the interrelationship among genotype, migraine, and incident CVD.
resultsAt baseline, 4,577 (18.3%) women reported history of migraine; 39.5% of the 3,226 women with active migraine indicated aura. During 11.9 years of follow-up, 625 CVD events occurred. We did not find an association of the ACE D/I polymorphism with migraine or migraine aura status. There was a lack of association between the ACE D/I polymorphism and incident major CVD, ischemic stroke, and myocardial infarction. Migraine with aura doubled the risk for CVD, but only for carriers of the DD (multivariable-adjusted relative risk [RR] = 2.10; 95% CI = 1.22-3.59; p = 0.007) and DI genotype (multivariable-adjusted RR = 2.31; 95% CI = 1.52-3.51; p < 0.0001). The risk was not significant among carriers of the II genotype, a pattern we observed for myocardial infarction and ischemic stroke.
conclusionsData from this large cohort of women do not suggest an association of the ACE deletion/insertion (D/I) polymorphism with migraine, migraine aura status, or cardiovascular disease (CVD). The increased risk for CVD among migraineurs with aura was only apparent for carriers of the DD/DI genotype. Due to limited number of outcome events, however, future studies are warranted to further investigate this association.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.