ArticleThe Journal of cell biology2009
Specific combinations of SR proteins associate with single pre-messenger RNAs in vivo and contribute different functions.
Article in The Journal of cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- RNA export through the nuclear pore complex is directional.Nature communications · 2022Article
- Integration of mRNP formation and export.Cellular and molecular life sciences : CMLS · 2017Review
- The control of alternative splicing by SRSF1 in myelinated afferents contributes to the development of neuropathic pain.Neurobiology of disease · 2016Article
- SR proteins are NXF1 adaptors that link alternative RNA processing to mRNA export.Genes & development · 2016Article
- Analysis of ERK3 intracellular localization: dynamic distribution during mitosis and apoptosis.European journal of histochemistry : EJH · 2015Article
- Intranuclear binding in space and time of exon junction complex and NXF1 to premRNPs/mRNPs in vivo.The Journal of cell biology · 2015Article
- Cyclin-dependent kinase 12 increases 3' end processing of growth factor-induced c-FOS transcripts.Molecular and cellular biology · 2015Article
- The Chironomus tentans genome sequence and the organization of the Balbiani ring genes.BMC genomics · 2014Article
- Article
- Limb-girdle muscular dystrophy 1F is caused by a microdeletion in the transportin 3 gene.Brain : a journal of neurology · 2013Article
- How cells get the message: dynamic assembly and function of mRNA-protein complexes.Nature reviews. Genetics · 2013Review
- RNA helicases in splicing.RNA biology · 2013Review
- Intimate liaison with SR proteins brings exon junction complexes to unexpected places.Nature structural & molecular biology · 2012Article
- The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.Cell · 2012Article
- SRSF1 regulates the assembly of pre-mRNA processing factors in nuclear speckles.Molecular biology of the cell · 2012Article
- Perturbation of chromatin structure globally affects localization and recruitment of splicing factors.PloS one · 2012Article
- Re-localization of cellular protein SRp20 during poliovirus infection: bridging a viral IRES to the host cell translation apparatus.PLoS pathogens · 2011Article
- Review
- Global analysis reveals SRp20- and SRp75-specific mRNPs in cycling and neural cells.Nature structural & molecular biology · 2010Article
- SR proteins in vertical integration of gene expression from transcription to RNA processing to translation.Molecular cell · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serine/arginine-rich (SR) proteins are required for messenger RNA (mRNA) processing, export, surveillance, and translation. We show that in Chironomus tentans, nascent transcripts associate with multiple types of SR proteins in specific combinations. Alternative splicing factor (ASF)/SF2, SC35, 9G8, and hrp45/SRp55 are all present in Balbiani ring (BR) pre-messenger ribonucleoproteins (mRNPs) preferentially when introns appear in the pre-mRNA and when cotranscriptional splicing takes place. However, hrp45/SRp55 is distributed differently in the pre-mRNPs along the gene compared with ASF/SF2, SC35, and 9G8, suggesting functional differences. All four SR proteins are associated with the BR mRNPs during export to the cytoplasm. Interference with SC35 indicates that SC35 is important for the coordination of splicing, transcription, and 3' end processing and also for nucleocytoplasmic export. ASF/SF2 is associated with polyribosomes, whereas SC35, 9G8, and hrp45/SRp55 cosediment with monoribosomes. Thus, individual endogenous pre-mRNPs/mRNPs bind multiple types of SR proteins during transcription, and these SR proteins accompany the mRNA and play different roles during the gene expression pathway in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.