ArticleThe Plant journal : for cell and molecular biology2009
Plant extracellular ATP signalling by plasma membrane NADPH oxidase and Ca2+ channels.
Article in The Plant journal : for cell and molecular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed, 203 citations in OpenAlex.
- Extracellular ATP: an emerging multifaceted regulator of plant fitness.Plant biotechnology journal · 2025Review
- Genome-Wide Analysis of Soybean Apyrase Gene Family and Functional Characterization of GmAPY1-4 Responses to Aluminum Stress.International journal of molecular sciences · 2025Article
- Purine-based infochemicals and immunometabolites: a comparative review of emerging signaling pathways in plants and animals.FEMS microbiology reviews · 2025Review
- CPK28 is a modulator of purinergic signaling in plant growth and defense.The Plant journal : for cell and molecular biology · 2024Article
- Extracellular Self- and Non-Self DNA Involved in Damage Recognition in the Mistletoe Parasitism of Mesquite Trees.International journal of molecular sciences · 2023Article
- The Plasma Membrane Purinoreceptor P2K1/DORN1 Is Essential in Stomatal Closure Evoked by Extracellular Diadenosine Tetraphosphate (ApInternational journal of molecular sciences · 2023Article
- Genome-Wide Investigation of Apyrase (APY) Genes in Peanut (International journal of molecular sciences · 2023Article
- ATANN3 Is Involved in Extracellular ATP-Regulated Auxin Distribution inPlants (Basel, Switzerland) · 2023Article
- Polarized distribution of extracellular nucleotides promotes gravity-directed polarization of development in spores ofFrontiers in plant science · 2023Article
- A histochemical reporter system to study extracellular ATP response in plants.Frontiers in plant science · 2023Article
- Article
- Comparative analysis of stress-induced calcium signals in the crop species barley and the model plant Arabidopsis thaliana.BMC plant biology · 2022Article
- Spatial origin of the extracellular ATP-induced cytosolic calcium signature in Arabidopsis thaliana roots: wave formation and variation with phosphate nutrition.Plant biology (Stuttgart, Germany) · 2022Article
- Extracellular ATP targets Arabidopsis RIBONUCLEASE 1 to suppress mycotoxin stress-induced cell death.The New phytologist · 2022Article
- The involvement of extracellular ATP in regulating the stunted growth of Arabidopsis plants by repeated wounding.BMC plant biology · 2022Article
- Arabidopsis thaliana CYCLIC NUCLEOTIDE-GATED CHANNEL2 mediates extracellular ATP signal transduction in root epidermis.The New phytologist · 2022Article
- Cyclic nucleotide-gated ion channel 6 is involved in extracellular ATP signaling and plant immunity.The Plant journal : for cell and molecular biology · 2022Article
- Phosphate-deprivation and damage signalling by extracellular ATP.Frontiers in plant science · 2022Article
- Calcium channels and transporters: Roles in response to biotic and abiotic stresses.Frontiers in plant science · 2022Review
- Plant Salinity Sensors: Current Understanding and Future Directions.Frontiers in plant science · 2022Review
16 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 7 institutions in 6 countries.
Funding
Abstract
Extracellular ATP regulates higher plant growth and adaptation. The signalling events may be unique to higher plants, as they lack animal purinoceptor homologues. Although it is known that plant cytosolic free Ca2+ can be elevated by extracellular ATP, the mechanism is unknown. Here, we have studied roots of Arabidopsis thaliana to determine the events that lead to the transcriptional stress response evoked by extracellular ATP. Root cell protoplasts were used to demonstrate that signalling to elevate cytosolic free Ca2+ is determined by ATP perception at the plasma membrane, and not at the cell wall. Imaging revealed that extracellular ATP causes the production of reactive oxygen species in intact roots, with the plasma membrane NADPH oxidase AtRBOHC being the major contributor. This resulted in the stimulation of plasma membrane Ca2+-permeable channels (determined using patch-clamp electrophysiology), which contribute to the elevation of cytosolic free Ca2+. Disruption of this pathway in the AtrbohC mutant impaired the extracellular ATP-induced increase in reactive oxygen species (ROS), the activation of Ca2+ channels, and the transcription of the MAP kinase3 gene that is known to be involved in stress responses. This study shows that higher plants, although bereft of purinoceptor homologues, could have evolved a distinct mechanism to transduce the ATP signal at the plasma membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.