ArticleMolecular and cellular biology1991
Yeast glycolytic mRNAs are differentially regulated.
Article in Molecular and cellular biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
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- Relief from nitrogen starvation triggers transient destabilization of glycolytic mRNAs inMolecular biology of the cell · 2018Article
- l-Arabinose triggers its own uptake via induction of the arabinose-specific Gal2p transporter in an industrialBiotechnology for biofuels · 2018Article
- Exocytosis and Endocytosis of Small Vesicles across the Plasma Membrane in Saccharomyces cerevisiae.Membranes · 2014Review
- Nuclear modifier MTO2 modulates the aminoglycoside-sensitivity of mitochondrial 15S rRNA C1477G mutation in Saccharomyces cerevisiae.PloS one · 2013Article
- Identification and partial characterization of extracellular aspartic protease genes from Metschnikowia pulcherrima IWBT Y1123 and Candida apicola IWBT Y1384.Applied and environmental microbiology · 2012Article
- Comparative proteomic analysis of transition of saccharomyces cerevisiae from glucose-deficient medium to glucose-rich medium.Proteome science · 2012Article
- Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitations.Molecular biology of the cell · 2010Article
- Metabolic adaptation of Phytophthora infestans during growth on leaves, tubers and artificial media.Molecular plant pathology · 2009Article
- Evidence that the transcription elongation function of Rpb9 is involved in transcription-coupled DNA repair in Saccharomyces cerevisiae.Molecular and cellular biology · 2006Article
- Global gene expression analysis of yeast cells during sake brewing.Applied and environmental microbiology · 2006Article
- Effects of depleting the essential central metabolic enzyme fructose-1,6-bisphosphate aldolase on the growth and viability of Candida albicans: implications for antifungal drug target discovery.Eukaryotic cell · 2006Article
- Genome-wide analysis of mRNA stability using transcription inhibitors and microarrays reveals posttranscriptional control of ribosome biogenesis factors.Molecular and cellular biology · 2004Article
- The unique features of glycolytic pathways in Archaea.The Biochemical journal · 2003Review
- Transcript analysis of 1003 novel yeast genes using high-throughput northern hybridizations.The EMBO journal · 2001Article
- Article
- The Candida albicans HYR1 gene, which is activated in response to hyphal development, belongs to a gene family encoding yeast cell wall proteins.Journal of bacteriology · 1996Article
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4 authors.
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Abstract
The regulation of glycolytic genes in response to carbon source in the yeast Saccharomyces cerevisiae has been studied. When the relative levels of each glycolytic mRNA were compared during exponential growth on glucose or lactate, the various glycolytic mRNAs were found to be induced to differing extents by glucose. No significant differences in the stabilities of the PFK2, PGK1, PYK1, or PDC1 mRNAs during growth on glucose or lactate were observed. PYK::lacZ and PGK::lacZ fusions were integrated independently into the yeast genome at the ura3 locus. The manner in which these fusions were differentially regulated in response to carbon source was similar to that of their respective wild-type loci. Therefore, the regulation of glycolytic mRNA levels is mediated at the transcriptional level. When the mRNAs are ordered with respect to the glycolytic pathway, two peaks of maximal induction are observed at phosphofructokinase and pyruvate kinase. These enzymes (i) catalyze the two essentially irreversible steps on the pathway, (ii) are the two glycolytic enzymes that are circumvented during gluconeogenesis and hence are specific to glycolysis, and (iii) are encoded by mRNAs that we have shown previously to be coregulated at the translational level in S. cerevisiae (P. A. Moore, A. J. Bettany, and A. J. P. Brown, NATO ASI Ser. Ser. H Cell Biol. 49:421-432, 1990). This differential regulation of glycolytic mRNA levels might therefore have a significant influence upon glycolytic flux in S. cerevisiae.
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