ArticleBritish journal of pharmacology2009
The role of PKA and PKCepsilon pathways in prostaglandin E2-mediated hypernociception.
Article in British journal of pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 78 citations in OpenAlex.
- Human Dorsal Root Ganglia Neuronal Cell Line to Study Nociceptive Signaling: A New Pipeline for Pain Therapy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- PGE2 Potentiates Orai1-Mediated Calcium Entry Contributing to Peripheral Sensitization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Biphasic Hormetic-like Effect of Lebecetin, a C-type Lectin of Snake Venom, on Formalin-induced Inflammation in Mice.Current neuropharmacology · 2024Article
- Chemogenetic Silencing of NaeNeuro · 2023Article
- Differential Antinociceptive Efficacy of Peel Extracts and Lyophilized Juices of Three Varieties of Mexican Pomegranate (Plants (Basel, Switzerland) · 2022Article
- The anti-inflamatory effect of Andira anthelmia lectin in rats involves inhibition of the prostanoid pathway, TNF-α and lectin domain.Molecular biology reports · 2022Article
- An LPARFrontiers in pain research (Lausanne, Switzerland) · 2022Article
- Activation of PKCε-ALDH2 Axis Prevents 4-HNE-Induced Pain in Mice.Biomolecules · 2021Article
- Article
- Antinociceptive Activity of the Skin Secretion ofToxins · 2020Article
- Novel Analgesics with Peripheral Targets.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception.Journal of neuroinflammation · 2020Review
- Developing Modern Pain Therapies.Frontiers in neuroscience · 2019Review
- Physical Activity Induces Nucleus Accumbens Genes Expression Changes Preventing Chronic Pain Susceptibility Promoted by High-Fat Diet and Sedentary Behavior in Mice.Frontiers in neuroscience · 2019Article
- Kinin Receptors Sensitize TRPV4 Channel and Induce Mechanical Hyperalgesia: Relevance to Paclitaxel-Induced Peripheral Neuropathy in Mice.Molecular neurobiology · 2018Article
- A Naphthoquinone from Sinningia canescens Inhibits Inflammation and Fever in Mice.Inflammation · 2017Article
- Opposing effects of prostaglandin EMolecular metabolism · 2017Article
- Peripheral Antinociception Induced by Aripiprazole Is Mediated by the Opioid System.BioMed research international · 2017Article
- Long-term exposure to PGE2 causes homologous desensitization of receptor-mediated activation of protein kinase A.Journal of neuroinflammation · 2016Article
- Extracellular matrix hyaluronan signals via its CD44 receptor in the increased responsiveness to mechanical stimulation.Neuroscience · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeProtein kinase (PK) A and the epsilon isoform of PKC (PKCepsilon) are involved in the development of hypernociception (increased sensitivity to noxious or innocuous stimuli) in several animal models of acute and persistent inflammatory pain. The present study evaluated the contribution of PKA and PKCepsilon to the development of prostaglandin E(2) (PGE(2))-induced mechanical hypernociception. EXPERIMENTAL APPROACH: Prostaglandin E(2)-induced mechanical hypernociception was assessed by constant pressure rat paw test. The activation of PKA or PKCepsilon was evaluated by radioactive enzymic assay in the dorsal root ganglia (DRG) of sensory neurons from the hind paws. KEY
resultsHypernociception induced by PGE(2) (100 ng) by intraplantar (i.pl.) injection, was reduced by i.pl. treatment with inhibitors of PKA [A-kinase-anchoring protein St-Ht31 inhibitor peptide (AKAPI)], PKCepsilon (PKCepsilonI) or adenylyl cyclase. PKA activity was essential in the early phase of the induction of hypernociception, whereas PKC activity was involved in the maintenance of the later phase of hypernociception. In the DRG (L4-L5), activity of PKA increased at 30 min after injection of PGE(2) but PKC activity increased only after 180 min. Moreover, i.pl. injection of the catalytic subunit of PKA induced hypernociception which was markedly reduced by pretreatment with an inhibitor of PKCepsilon, while the hypernociception induced by paw injection of PKCepsilon agonist was not affected by an inhibitor of PKA (AKAPI). CONCLUSIONS AND IMPLICATIONS: Taken together, these findings are consistent with the suggestion that PKA activates PKCepsilon, which is a novel mechanism of interaction between these kinases during the development of PGE(2)-induced mechanical hypernociception.
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