ArticleMolecular and cellular biology1991
Regulation and a possible stage-specific function of Oct-2 during pre-B-cell differentiation.
Article in Molecular and cellular biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- OCT-2 Is Associated With Pro-Metastatic Epigenomic Properties of Triple-Negative Breast Cancer Cells.Cancer science · 2025Article
- A novel role for Oct-2 in the lipopolysaccharide-mediated induction of resistin gene expression in RAW264.7 cells.The Biochemical journal · 2007Article
- Oct transcription factors mediate t(14;18) lymphoma cell survival by directly regulating bcl-2 expression.Oncogene · 2006Article
- Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Using altered specificity Oct-1 and Oct-2 mutants to analyze the regulation of immunoglobulin gene transcription.The EMBO journal · 1997Article
- Coordinate transcription and V(D)J recombination of the kappa immunoglobulin light-chain locus: NF-kappaB-dependent and -independent pathways of activation.Molecular and cellular biology · 1997Article
- Gene structure and characterization of the murine homologue of the B cell-specific transcriptional coactivator OBF-1.Nucleic acids research · 1996Article
- In vivo footprinting of the mouse inducible nitric oxide synthase gene: inducible protein occupation of numerous sites including Oct and NF-IL6.Nucleic acids research · 1996Article
- The chicken immunoglobulin lambda light chain gene is transcriptionally controlled by a modularly organized enhancer and an octamer-dependent silencer.Nucleic acids research · 1995Article
- Diphosphoryl lipid A from Rhodobacter sphaeroides transiently activates NF-kappa B but inhibits lipopolysaccharide induction of kappa light chain and Oct-2 in the B-cell lymphoma line 70Z/3.Infection and immunity · 1995Article
- Regional induction of tumor necrosis factor alpha expression in the mouse brain after systemic lipopolysaccharide administration.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Qualitative changes in the subunit composition of kappa B-binding complexes during murine B-cell differentiation.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Two different IFN-gamma nonresponsive variants derived from the B-cell lymphoma 70Z/3.Immunogenetics · 1994Article
- Genetic analysis of transcription factors implicated in B lymphocyte development.Immunologic research · 1994Review
- Targeted disruption of the Oct-2 locus in a B cell provides genetic evidence for two distinct cell type-specific pathways of octamer element-mediated gene activation.The EMBO journal · 1993Article
- Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family.Molecular and cellular biology · 1993Article
- Transforming growth factor beta and cyclosporin A inhibit the inducible activity of the interleukin-2 gene in T cells through a noncanonical octamer-binding site.Molecular and cellular biology · 1993Article
- Compilation of vertebrate-encoded transcription factors.Nucleic acids research · 1992Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The Oct-2 gene appears to encode a developmental regulator of immunoglobulin gene transcription. We demonstrate that the Oct-2 gene is expressed at low levels in a variety of transformed pre-B-cell lines and is induced specifically in these cells by lipopolysaccharide signalling. This work extends an earlier observation in the pre-B-cell line 70Z/3 and therefore suggests that the inducible expression of the Oct-2 gene, like that of the kappa gene, is a characteristic feature of the pre-B stage of B-cell development. In 70Z/3 cells, the lymphokine interleukin-1 also induces the expression of the Oct-2 and kappa loci. Interestingly, expression of the Oct-2 gene is rapidly induced at the transcriptional level and may not require de novo protein synthesis. Since the changes in the activity of the Oct-2 locus completely correlate with the changes of the activity of the kappa locus, the two genes may be transcriptionally regulated by a common trans-acting factor. In 70Z/3 cells, transforming growth factor beta, an inhibitor of kappa-gene induction, blocks the upregulation of Oct-2 but not the activation of NF-kappa B. These results suggest that the combinatorial action of increased levels of Oct-2 and activated NF-kappa B may be necessary for the proper stage-specific expression of the kappa locus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.