Trial reportThe Journal of infectious diseases2009
Factors associated with the prevalence and incidence of herpes simplex virus type 2 infection among men in Rakai, Uganda.
Trial report in The Journal of infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Trial of Male Circumcision: HIV, STD and Behavioral Effects in Men, Women and the Community
Randomized Trial of Male Circumcision for HIV Prevention, Rakai, Uganda
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Critical evaluation of arguments opposing male circumcision: A systematic review.Journal of evidence-based medicine · 2019Pooled it
- Disclosure of HSV-2 serological test results in the context of an adolescent HIV prevention trial in Kenya.Sexually transmitted infections · 2015Trial
- Medical male circumcision and herpes simplex virus 2 acquisition: posttrial surveillance in Kisumu, Kenya.The Journal of infectious diseases · 2013Trial
- Daily acyclovir to decrease herpes simplex virus type 2 (HSV-2) transmission from HSV-2/HIV-1 coinfected persons: a randomized controlled trial.The Journal of infectious diseases · 2013Trial
- Reactivation of herpes simplex virus type 2 after initiation of antiretroviral therapy.The Journal of infectious diseases · 2013Trial
- Male circumcision and herpes simplex virus type 2 infection in female partners: a randomized trial in Rakai, Uganda.The Journal of infectious diseases · 2012Trial
- Foreskin inflammation is associated with HIV and herpes simplex virus type-2 infections in Rakai, Uganda.AIDS (London, England) · 2009Trial
- Incident HIV and herpes simplex virus type 2 infection among men in Rakai, Uganda.AIDS (London, England) · 2009Trial
- Novel penile circumcision suturing devices versus the shang ring for adult male circumcision: a prospective study.International braz j urol : official journal of the Brazilian Society of UrologyTrial
- Does the evidence support circumcision of infant males in the United Kingdom?-a systematic review.Translational andrology and urology · 2026Review
- Neonatal Male Circumcision: Clearly Beneficial for Public Health or an Ethical Dilemma? A Systematic Review.Cureus · 2024Review
- Comments by opponents on the British Medical Association's guidance on non-therapeutic male circumcision of children seem one-sided and may undermine public health.World journal of clinical pediatrics · 2023Article
- Age Patterns of HSV-2 Incidence and Prevalence in Two Ugandan Communities: A Catalytic Incidence Model Applied to Population-Based Seroprevalence Data.The Journal of infectious diseases · 2023Article
- Infant Circumcision for Sexually Transmitted Infection Risk Reduction Globally.Global health, science and practice · 2022Article
- Evidence-based circumcision policy for Australia.Journal of men's health · 2022Article
- Carrageenan-Based Acyclovir Mucoadhesive Vaginal Tablets for Prevention of Genital Herpes.Marine drugs · 2020Article
- Females' Peer Influence and Support for Adolescent Males Receiving Voluntary Medical Male Circumcision Services.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Canadian Urological Association guideline on the care of the normal foreskin and neonatal circumcision in Canadian infants (abridged version).Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2018Article
- Canadian Urological Association guideline on the care of the normal foreskin and neonatal circumcision in Canadian infants (full version).Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2018Article
- Dorsal longitudinal foreskin cut is associated with reduced risk of HIV, syphilis and genital herpes in men: a cross-sectional study in Papua New Guinea.Journal of the International AIDS Society · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
Abstract
Little is known about risk factors for incident herpes simplex virus type 2 (HSV-2) infection among men in Africa. In a trial in Rakai, Uganda, 6396 men aged 15-49 years were evaluated for serological evidence of HSV-2, human immunodeficiency virus (HIV), and syphilis infections at enrollment and at 6, 12, and 24 months. The prevalence of HSV-2 infection was 33.76%, and the incidence was 4.90 cases per 100 person-years. HSV-2 incidence increased with alcohol use with sexual intercourse (adjusted incidence rate ratio [adjIRR], 1.92 [95% confidence interval {CI}, 1.46-2.53]), decreased with consistent condom use (adjIRR, 0.56 [95% CI, 0.36-0.89]) and male circumcision (adjIRR, 0.70 [95% CI, 0.55-0.91]), and was not significantly affected by enrollment HIV status. Education on modifiable behavioral changes may reduce the acquisition of HSV-2. (ClinicalTrials.gov identifiers: NCT00425984 and NCT00124878 .).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.