ReviewMedicinal research reviews2009
Nitrite as regulator of hypoxic signaling in mammalian physiology.
Review in Medicinal research reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03371966 (The Effects of Chronic Dietary Nitrate Supplementation on Constant Work Rate Exercise in High Functioning Middle Aged and Older Adults), which is not on this map. Cited by 177 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Chronic Dietary Nitrate Supplementation on Constant Work Rate Exercise in High Functioning Middle Aged and Older Adults
Who cites it
177 citing papers in PubMed, 2 syntheses or guidelines pooled it, 426 citations in OpenAlex.
- The Impact of Inorganic Nitrate on Endothelial Function: A Systematic Review of Randomized Controlled Trials and Meta-analysis.Nutrition reviews · 2026Pooled it
- Effects of Dietary Nitrates on Time Trial Performance in Athletes with Different Training Status: Systematic Review.Nutrients · 2020Pooled it
- Influence of Acute Beetroot Juice Intake on Agility Performance Immediately Post-Repeated Maximal Sprinting in Soccer Players.Nutrients · 2026Trial
- Double-blind controlled dietary cross-over intervention with differentially fertilised intact lettuce leaves shows acute reduction in blood pressure in young adults, associated with faster uptake of nitrate than of phenolics.European journal of nutrition · 2022Trial
- Inorganic nitrate supplementation and blood flow restricted exercise tolerance in post-menopausal women.Nitric oxide : biology and chemistry · 2022Trial
- Independent and combined impact of hypoxia and acute inorganic nitrate ingestion on thermoregulatory responses to the cold.European journal of applied physiology · 2021Trial
- Human skeletal muscle nitrate store: influence of dietary nitrate supplementation and exercise.The Journal of physiology · 2019Trial
- Eight weeks of nitrate supplementation improves blood flow and reduces the exaggerated pressor response during forearm exercise in peripheral artery disease.American journal of physiology. Heart and circulatory physiology · 2018Trial
- Acute dietary nitrate supplementation enhances compensatory vasodilation during hypoxic exercise in older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Trial
- Single-dose pharmacokinetics of different oral sodium nitrite formulations in diabetes patients.Diabetes technology & therapeutics · 2012Trial
- Inorganic nitrate ingestion improves vascular compliance but does not alter flow-mediated dilatation in healthy volunteers.Nitric oxide : biology and chemistry · 2012Trial
- Dietary nitrate reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia.The Journal of physiology · 2011Trial
- Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Trial
- Review
- Beetroot Plus Vitamin C for Performance and Recovery: Protocol of a Double-Blind, Placebo-Controlled, Randomized Crossover Trial in Semi-Professional Wrestlers.Health science reports · 2026Article
- Effects of Continuous Low-dose Nitric Oxide in a Murine Model of Pulmonary Hypertension with Impaired Lung Development.Anesthesiology · 2026Article
- Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations.International journal of molecular sciences · 2026Review
- The chemistry of the nitrate-nitrite-nitric oxide pathway: regulating muscle oxygenation and exercise performance.RSC advances · 2026Review
- Special Issue "Amino Acids and Related Compounds in Health and Disease".International journal of molecular sciences · 2025Article
- Integrative Neuroimmune Role of the Parasympathetic Nervous System, Vagus Nerve and Gut Microbiota in Stress Modulation: A Narrative Review.International journal of molecular sciences · 2025Review
117 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 14 institutions in 8 countries.
Funding
Abstract
In this review we consider the effects of endogenous and pharmacological levels of nitrite under conditions of hypoxia. In humans, the nitrite anion has long been considered as metastable intermediate in the oxidation of nitric oxide radicals to the stable metabolite nitrate. This oxidation cascade was thought to be irreversible under physiological conditions. However, a growing body of experimental observations attests that the presence of endogenous nitrite regulates a number of signaling events along the physiological and pathophysiological oxygen gradient. Hypoxic signaling events include vasodilation, modulation of mitochondrial respiration, and cytoprotection following ischemic insult. These phenomena are attributed to the reduction of nitrite anions to nitric oxide if local oxygen levels in tissues decrease. Recent research identified a growing list of enzymatic and nonenzymatic pathways for this endogenous reduction of nitrite. Additional direct signaling events not involving free nitric oxide are proposed. We here discuss the mechanisms and properties of these various pathways and the role played by the local concentration of free oxygen in the affected tissue.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.