ArticleJournal of mathematical biology2009
A mathematical model of blood, cerebrospinal fluid and brain dynamics.
Article in Journal of mathematical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed.
- Cerebrovascular Imaging-to-Graph Reconstruction for Individualized Digital Twin Brains.bioRxiv : the preprint server for biology · 2026Article
- Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis.Nature biomedical engineering · 2026Article
- On reduced-order modeling of drug dispersion in the spinal canal.Fluids and barriers of the CNS · 2025Article
- The heartbeat induces local volumetric compression in the healthy human brain: a 7 T magnetic resonance imaging study on brain tissue pulsations.Interface focus · 2024Article
- Regulation of brain fluid volumes and pressures: basic principles, intracranial hypertension, ventriculomegaly and hydrocephalus.Fluids and barriers of the CNS · 2024Review
- Predicting shock-induced cavitation using machine learning: implications for blast-injury models.Frontiers in bioengineering and biotechnology · 2024Article
- Pulsatile cerebral paraarterial flow by peristalsis, pressure and directional resistance.Fluids and barriers of the CNS · 2023Article
- Cerebrospinal Fluid Flow.Annual review of fluid mechanics · 2023Article
- A mechanistic pharmacokinetic model for intrathecal administration of antisense oligonucleotides.Frontiers in physiology · 2023Article
- Long-term recovery behavior of brain tissue in hydrocephalus patients after shunting.Communications biology · 2022Article
- The glymphatic system: Current understanding and modeling.iScience · 2022Review
- Effect of cilia-induced surface velocity on cerebrospinal fluid exchange in the lateral ventricles.Journal of the Royal Society, Interface · 2022Article
- Cerebrospinal fluid dynamics coupled to the global circulation in holistic setting: Mathematical models, numerical methods and applications.International journal for numerical methods in biomedical engineering · 2022Article
- A New Definition for Intracranial Compliance to Evaluate Adult Hydrocephalus After Shunting.Frontiers in bioengineering and biotechnology · 2022Article
- Influence of interaction of cerebral fluids on ventricular deformation: A mathematical approach.PloS one · 2022Article
- Peak ependymal cell stretch overlaps with the onset locations of periventricular white matter lesions.Scientific reports · 2021Article
- Interactions of brain, blood, and CSF: a novel mathematical model of cerebral edema.Fluids and barriers of the CNS · 2021Article
- Hemodynamic Patterns of Spinal Cord Perfusion in Thoracoabdominal Aortic Aneurysm Repair.Aorta (Stamford, Conn.) · 2021Article
- Proposed mechanism for reduced jugular vein flow in microgravity.Physiological reports · 2021Article
- Novel PET Biomarkers to Disentangle Molecular Pathways across Age-Related Neurodegenerative Diseases.Cells · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Using first principles of fluid and solid mechanics a comprehensive model of human intracranial dynamics is proposed. Blood, cerebrospinal fluid (CSF) and brain parenchyma as well as the spinal canal are included. The compartmental model predicts intracranial pressure gradients, blood and CSF flows and displacements in normal and pathological conditions like communicating hydrocephalus. The system of differential equations of first principles conservation balances is discretized and solved numerically. Fluid-solid interactions of the brain parenchyma with cerebral blood and CSF are calculated. The model provides the transitions from normal dynamics to the diseased state during the onset of communicating hydrocephalus. Predicted results were compared with physiological data from Cine phase-contrast magnetic resonance imaging to verify the dynamic model. Bolus injections into the CSF are simulated in the model and found to agree with clinical measurements.
Indexed as
Identifiers
19219605What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.