ArticleNeurogenetics2009
Association between migraine and a functional polymorphism at the dopamine beta-hydroxylase locus.
Article in Neurogenetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Identification of a novel ANKK1 and other dopaminergic (DRD2 and DBH) gene variants in migraine susceptibility.Neuromolecular medicine · 2013Pooled it
- Meta-analysis of genome-wide association for migraine in six population-based European cohorts.European journal of human genetics : EJHG · 2011Pooled it
- Dopaminergic Dysregulation in Migraine: From Hypothalamic A11 Dysfunction to a Systemic Biobehavioral Phenotype.International journal of molecular sciences · 2026Review
- The Dawn and Advancement of the Knowledge of the Genetics of Migraine.Journal of clinical medicine · 2024Review
- Candidate gene association study suggests potential role of dopamine beta-hydroxylase in pain heterogeneity in sickle cell disease.Frontiers in genetics · 2023Article
- A Comprehensive Review on the Role of Genetic Factors in the Pathogenesis of Migraine.Journal of molecular neuroscience : MN · 2021Review
- Influence ofJournal of pharmacy & bioallied sciences · 2020Article
- Dopamine-beta-hydroxylase 19-bp insertion/deletion polymorphism affects medication overuse in patients with chronic migraine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Association of expression ofJournal of pain research · 2018Article
- Comorbidity of Alcohol Use Disorder and Chronic Pain: Genetic Influences on Brain Reward and Stress Systems.Alcoholism, clinical and experimental research · 2017Review
- Characterization of SNPs in the dopamine-β-hydroxylase gene providing new insights into its structure-function relationship.Neurogenetics · 2017Article
- Migraine genetics: current findings and future lines of research.Neurogenetics · 2015Article
- Case-control study of ADARB1 and ADARB2 gene variants in migraine.The journal of headache and pain · 2015Article
- Regulatory polymorphisms in human DBH affect peripheral gene expression and sympathetic activity.Circulation research · 2014Article
- Our evolving understanding of migraine with aura.Current pain and headache reports · 2014Review
- Studies on the pathophysiology and genetic basis of migraine.Current genomics · 2013Article
- Thr698Thr (nt2369) polymorphism on CACNA1A gene and head pain severity in familial migraine.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013Article
- The effects of DBH, MAOA, and MAOB on attentional biases for facial expressions.Journal of molecular neuroscience : MN · 2013Article
- Variants in the human potassium channel gene (KCNN3) are associated with migraine in a high risk genetic isolate.The journal of headache and pain · 2011Article
- Identification of molecular genetic factors that influence migraine.Molecular genetics and genomics : MGG · 2011Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migraine is a common neurological disorder with a significant genetic component. Although a number of linkage and association studies have been undertaken, the number and identity of all migraine susceptibility genes has yet to be defined. The existence of dopaminergic hypersensitivity in migraine has been recognised on a pharmacological basis and some studies have reported genetic association between migraine and dopamine-related gene variants. Our laboratory has previously reported association of migraine with a promoter STR marker in the dopamine beta hydroxylase (DBH) gene. In the present study, we analysed two additional DBH markers in two independent migraine case-control cohorts. These two markers are putative functional SNPs, one within the promoter (-1021C-->T) and another SNP (+1603C-->T) in exon 11 of the DBH gene. The results showed a significant association for allelic and genotypic frequency distribution between the DBH marker in the promoter and migraine in the first (P = 0.004 and P = 0.012, respectively) and the second (P = 0.013 and P = 0.031, respectively) tested cohorts. There was no association observed between either genotype and/or allelic frequencies for the DBH marker located in exon 11 and migraine (P > or = 0.05). The promoter DBH marker, reported associated with migraine in this study, has been shown to affect up to 52% of plasma DBH activity. Varying DBH activity levels have been postulated to be involved in migraine process with an increase of dopamine, resulting from a lower DBH activity shown positively correlated with migraine severity. It is plausible that the functional promoter variant of DBH may play a role in the migraine disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.