ArticlePediatric nephrology (Berlin, Germany)2009
Minimal change disease with IgM+ immunofluorescence: a subtype of nephrotic syndrome.
Article in Pediatric nephrology (Berlin, Germany), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- The natural history of immunoglobulin M nephropathy in adults.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2017Trial
- Prediction Models and Risk Factors for Steroid Resistance in Children with Nephrotic Syndrome: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- To biopsy or not to biopsy a teenager with idiopathic nephrotic syndrome? Biopsy first.Pediatric nephrology (Berlin, Germany) · 2025Article
- IgM deposition is a risk factor for delayed remission and early relapse of the pediatric minimal change disease.Frontiers in pediatrics · 2023Article
- Clinical relevance of glomerular IgM deposition in patients with lupus nephritis.BMC immunology · 2021Article
- IgM mesangial deposition as a risk factor for relapses of adult-onset minimal change disease.BMC nephrology · 2021Article
- Clinical significance of IgM deposition in pediatric minimal change disease.International journal of pediatrics & adolescent medicine · 2019Article
- A case report of immunoglobulin M nephropathy manifesting as crescentic glomerulonephritis and nephrotic syndrome in an adult.BMC nephrology · 2019Article
- IgM as a novel predictor of disease progression in secondary focal segmental glomerulosclerosis.Croatian medical journal · 2017Article
- The impact of IgM deposits on the outcome of Nephrotic syndrome in children.BMC nephrology · 2017Article
- Glomerular Filtration Rate Trends During Follow-up in Children With Steroid-Sensitive Nephrotic Syndrome.Canadian journal of kidney health and disease · 2017Article
- IgM nephropathy: is it closer to minimal change disease or to focal segmental glomerulosclerosis?Journal of nephrology · 2016Review
- Prevalence of Glomerulopathies in Canine Mammary Carcinoma.PloS one · 2016Article
- IgM exacerbates glomerular disease progression in complement-induced glomerulopathy.Kidney international · 2015Article
- Do C1q or IgM nephropathies predict disease severity in children with minimal change nephrotic syndrome?Pediatric nephrology (Berlin, Germany) · 2014Article
- IgM nephropathy; can we still ignore it.Journal of nephropathology · 2013Review
- Is cyclophosphamide effective in patients with IgM-positive minimal change disease?Pediatric nephrology (Berlin, Germany) · 2012Article
- IgM nephropathy in India: a single centre experience.Indian journal of pediatrics · 2012Article
- Significance of electron dense deposits in patients with minimal change nephrotic syndrome.Korean journal of pathology · 2012Article
- Mycophenolate mofetil (MMF) treatment efficacy in children with primary and secondary glomerulonephritis.Archives of medical science : AMS · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunoglobulin (Ig) M nephropathy is defined by electron-dense mesangial deposits and mesangial IgM visible by immunofluorescence (IF) without other histopathologic and immunofluorescent microscopic abnormalities. Certain patients have only immuno-positive (IgM+) IF. Children presenting with steroid-dependent or steroid-resistant nephrotic syndrome have a high prevalence of IgM+ IF with or without electron-dense deposits. We reviewed the clinical course of children with steroid-dependent or steroid-resistant nephrotic syndrome who underwent renal biopsy at Texas Children's Hospital from 1989 to 2006 to further characterize IgM+ IF in children with nephrotic syndrome. Of the 55 children with steroid-resistant or -dependent minimal change disease (MCD), 23 had IgM+ IF. Of these 23 children, 61% had microscopic hematuria at presentation, 48% (11/23) were steroid-dependent, and 48% (11/23) steroid-resistant (one underwent biopsy prior to steroid therapy). We compared the efficacy of adjuvant treatment with cyclophosphamide and cyclosporine: 18% initially treated with cyclophosphamide obtained remission, while 55% had no response; 83% obtained subsequent remission with cyclosporine. Of those initially treated with cyclosporine, 88% obtained complete or partial remission. IgM+ IF may be surrogate marker for the severity of MCD. Based on our results, children with MCD and IgM+ IF have a better response to cyclosporine than cyclophosphamide.
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