ArticleClinical research in cardiology : official journal of the German Cardiac Society2009
Prognostic value of heart rate variability and ventricular arrhythmias during 13-year follow-up in patients with mild to moderate heart failure.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04554160 (ArrhythmiaS in Pulmonary arterIal hypeRtEnsion and Right Heart Failure Assessed by Continuous Long-term Cardiac Monitoring), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ArrhythmiaS in Pulmonary arterIal hypeRtEnsion and Right Heart Failure Assessed by Continuous Long-term Cardiac Monitoring
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prediction of heart rate variability on cardiac sudden death in heart failure patients: a systematic review.International journal of cardiology · 2014Pooled it
- Pooled it
- Heart Rate Variability Analysis in Congestive Heart Failure: The Need for Standardized Assessment Protocols.Reviews in cardiovascular medicine · 2025Review
- Heart Rate Variability's Value in Predicting Out-of-Hospital Major Adverse Cardiovascular Events in Patients With Chronic Heart Failure.Cardiovascular therapeutics · 2025Article
- Depression Associated with Reduced Heart Rate Variability Predicts Outcome in Adult Congenital Heart Disease.Journal of clinical medicine · 2021Article
- Patients with exercise-associated ventricular ectopy present evidence of myocarditis.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2015Article
- Cloud-Based Smart Health Monitoring System for Automatic Cardiovascular and Fall Risk Assessment in Hypertensive Patients.Journal of medical systems · 2015Observational
- A real-world perspective on the prevalence and treatment of heart failure with a reduced ejection fraction but no specific or only mild symptoms.Heart failure reviews · 2015Review
- Association of hypertension status and cardiovascular risks with sympathovagal imbalance in first degree relatives of type 2 diabetics.Journal of diabetes investigation · 2014Article
- Prognostic significance of heart rate turbulence parameters in patients with chronic heart failure.BMC cardiovascular disorders · 2014Article
- Accurate prediction of coronary artery disease using reliable diagnosis system.Journal of medical systems · 2012Article
- Influence of algorithm-based analgesia and sedation in patients after sudden cardiac arrest.Clinical research in cardiology : official journal of the German Cardiac Society · 2012Article
- Autonomic regulation during mild therapeutic hypothermia in cardiopulmonary resuscitated patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2011Article
- Daytime baroreflex sensitivity in patients with primary insomnia.Clinical research in cardiology : official journal of the German Cardiac Society · 2011Article
- Heart rate variability and biomarkers of systemic inflammation in patients with stable coronary heart disease: findings from the Heart and Soul Study.Clinical research in cardiology : official journal of the German Cardiac Society · 2011Article
- Discrimination power of long-term heart rate variability measures for chronic heart failure detection.Medical & biological engineering & computing · 2011Article
- Prognostic value of galectin-3, a novel marker of fibrosis, in patients with chronic heart failure: data from the DEAL-HF study.Clinical research in cardiology : official journal of the German Cardiac Society · 2010Article
- Fractal scaling properties of heart rate dynamics and myocardial efficiency in dilated cardiomyopathy.Clinical research in cardiology : official journal of the German Cardiac Society · 2009Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn contrast to patients with moderate to severe chronic heart failure (CHF), data regarding long-term outcome in patients with mild CHF are scarce. We examined the place of Holter monitoring to study the prognostic value of ventricular arrhythmias and heart rate variability (HRV) in patients with mild to moderate CHF during long-term follow-up.
methodsWe studied 90 patients with mild to moderate CHF and NYHA class II who had been enrolled in the Dutch Ibopamine Multicenter Trial. At baseline their mean age was 60.5 +/- 8.0 years, left ventricular ejection fraction (LVEF) was 0.29 +/- 0.09, and 85% were males. At the start of the study, patients were only using diuretics, while digoxin, and particularly ACE inhibitors and beta-blockers were initiated later. Univariate and multivariate proportional hazard analyses were performed.
resultsAt baseline 80% of patients were in NYHA class II, and 20% were in class III; their mean age was 60 years, mean LVEF was 0.29, and 85% were men. During a follow-up of 13 years, 47 patients (53%) died. Cardiovascular (CV) death occurred in 39 patients, of which 28 were sudden cardiac death (SCD). For both CV death and SCD, LVEF <30% and ventricular premature beats/h (>20) were independent risk markers. Of the HRV parameters, total power (>2,500 ms(2)) was an important risk marker for CV death, but not for SCD.
conclusionThe present 13-year follow-up study in 90 patients with mild to moderate CHF showed that ventricular premature beats and HRV may have important value in predicting outcome.
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