ArticleBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2009
Synaptic vesicle pool size, release probability and synaptic depression are sensitive to Ca2+ buffering capacity in the developing rat calyx of Held.
Article in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 31 citations in OpenAlex.
- Munc13-1 couples DAG and CaScience advances · 2026Article
- Nifedipine Ameliorates Cellular Differentiation Defects of Smn-Deficient Motor Neurons and Enhances Neuromuscular Transmission in SMA Mice.International journal of molecular sciences · 2023Article
- Hair Cell Afferent Synapses: Function and Dysfunction.Cold Spring Harbor perspectives in medicine · 2019Review
- Developmental Synaptic Changes at the Transient Olivocochlear-Inner Hair Cell Synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The Coupling between CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Some Subtle Lessons from the Calyx of Held Synapse.Biophysical journal · 2017Review
- Molecular Machines Regulating the Release Probability of Synaptic Vesicles at the Active Zone.Frontiers in synaptic neuroscience · 2016Review
- Complexin stabilizes newly primed synaptic vesicles and prevents their premature fusion at the mouse calyx of held synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Developmental tightening of cerebellar cortical synaptic influx-release coupling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Proton-mediated block of Ca2+ channels during multivesicular release regulates short-term plasticity at an auditory hair cell synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Presynaptic nanodomains: a tale of two synapses.Frontiers in cellular neuroscience · 2014Review
- Single Ca2+ channels and exocytosis at sensory synapses.The Journal of physiology · 2013Review
- The calyx of Held develops adult-like dynamics and reliability by hearing onset in the mouse in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Article
- Exocytotic dynamics and calcium cooperativity effects in the calyx of Held synapse: a modelling study.Journal of computational neuroscience · 2010Article
- Action potential evoked transmitter release in central synapses: insights from the developing calyx of Held.Molecular brain · 2009Review
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
The calyx of Held, a specialized synaptic terminal in the medial nucleus of the trapezoid body, undergoes a series of changes during postnatal development that prepares this synapse for reliable high frequency firing. These changes reduce short-term synaptic depression during tetanic stimulation and thereby prevent action potential failures during a stimulus train. We measured presynaptic membrane capacitance changes in calyces from young postnatal day 5-7 (p5-7) or older (p10-12) rat pups to examine the effect of calcium buffer capacity on vesicle pool size and the efficiency of exocytosis. Vesicle pool size was sensitive to the choice and concentration of exogenous Ca2+ buffer, and this sensitivity was much stronger in younger animals. Pool size and exocytosis efficiency in p5-7 calyces were depressed by 0.2 mM EGTA to a greater extent than with 0.05 mM BAPTA, even though BAPTA is a 100-fold faster Ca2+ buffer. However, this was not the case for p10-12 calyces. With 5 mM EGTA, exocytosis efficiency was reduced to a much larger extent in young calyces compared to older calyces. Depression of exocytosis using pairs of 10-ms depolarizations was reduced by 0.2 mM EGTA compared to 0.05 mM BAPTA to a similar extent in both age groups. These results indicate a developmentally regulated heterogeneity in the sensitivity of different vesicle pools to Ca2+ buffer capacity. We propose that, during development, a population of vesicles that are tightly coupled to Ca2+ channels expands at the expense of vesicles more distant from Ca2+ channels.
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