ArticleInvestigative ophthalmology & visual science2009
Neurologic evaluation of acute lacrimomimetic effect of cyclosporine in an experimental rabbit dry eye model.
Article in Investigative ophthalmology & visual science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03666884 (The Comparison of 50 % Concentration Autologous Serum Eye Drops Versus Preservative Free Artificial Eye Drop Plus 0.05 % Cyclosporin Ophthalmic Emulsion in the Treatment of Severe Dry Eye Syndrome), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Comparison of 50 % Concentration Autologous Serum Eye Drops Versus Preservative Free Artificial Eye Drop Plus 0.05 % Cyclosporin Ophthalmic Emulsion in the Treatment of Severe Dry Eye Syndrome: A Randomized Comparative Study
Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Comparative study of the therapeutic effects of different medications on DM-associated dry eye syndrome after vitrectomy.Frontiers in medicine · 2026Article
- P2X4 Receptor Antagonist Ameliorates Ocular Pain in Rats After Lacrimal Gland Removal.Translational vision science & technology · 2025Article
- Cyclosporine A Decreases Dryness-Induced Hyperexcitability of Corneal Cold-Sensitive Nerve Terminals.International journal of molecular sciences · 2023Article
- Astragalus Ⅳ ameliorates the dry eye injury in rabbit model <em>via</em> MUC1-ErbB1 pathway.European journal of histochemistry : EJH · 2021Article
- TFOS DEWS II Tear Film Report.The ocular surface · 2017Review
- Age-related Defects in Ocular and Nasal Mucosal Immune System and the Immunopathology of Dry Eye Disease.Ocular immunology and inflammation · 2016Review
- Hyperosmolar Tears Induce Functional and Structural Alterations of Corneal Nerves: Electrophysiological and Anatomical Evidence Toward Neurotoxicity.Investigative ophthalmology & visual science · 2015Article
- Therapeutic Strategies to Treat Dry Eye in an Aging Population.Drugs & aging · 2015Review
- Tear-mediated delivery of nanoparticles through transcytosis of the lacrimal gland.Journal of controlled release : official journal of the Controlled Release Society · 2015Article
- Efficacy of retinol palmitate eye drops for dry eye in rabbits with lacrimal gland resection.Clinical ophthalmology (Auckland, N.Z.) · 2012Article
- Lacritin, a novel human tear glycoprotein, promotes sustained basal tearing and is well tolerated.Investigative ophthalmology & visual science · 2011Article
- Cyclosporine ophthalmic emulsions for the treatment of dry eye: a review of the clinical evidence.Clinical investigationArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
purposeTo evaluate neurologically acute lacrimation caused by cyclosporine (CsA) eyedrops in rabbit.
methodsNormal adult male New Zealand White rabbits and those that underwent parasympathectomy each received a single instillation of 0.1% CsA or vehicle eyedrops. Schirmer tear test (STT) results, flow rate of lacrimal gland (LG) fluid from the excretory lacrimal duct of the main LG, and blink rate (over a 3-minute period) were measured before and after instillation of CsA or vehicle. Light microscopy was performed to examine the main LG in vitro. Protein release from LG fragments was assessed after incubation with CsA for 30 minutes.
resultsIn normal rabbits, the STT value and the flow rate of LG fluid were significantly increased after treatment with CsA compared with vehicle (P < 0.05). In contrast, no changes were found in denervated eyes. The blink rate of CsA-treated eyes was significantly higher than that of vehicle-treated eyes in normal rabbits (P < 0.005), whereas that of denervated eyes decreased significantly after CsA instillation compared with before administration (P < 0.005). Light microscopy showed that the cytoplasm of acinar cells was packed with secretory granules in denervated LG tissue 7 days after parasympathectomy. The same finding was observed 3 hours after CsA instillation. CsA had no stimulatory effect on protein release by acinar cells in LG fragments at all concentrations tested.
conclusionsThese results suggest that CsA has no direct effect on tear fluid secretion from the LG in an acute model. Instead, CsA increases reflex tear flow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.