ArticleThe Journal of biological chemistry2009
Krox20 controls the transcription of its various targets in the developing hindbrain according to multiple modes.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- Identification of a neural development gene expression signature in colon cancer stem cells reveals a role foriScience · 2022Article
- A regulatory variant in TBX2 promoter is related to the decreased susceptibility of congenital heart disease in the Han Chinese population.Molecular genetics & genomic medicine · 2019Article
- Analysis of novel caudal hindbrain genes reveals different regulatory logic for gene expression in rhombomere 4 versus 5/6 in embryonic zebrafish.Neural development · 2018Article
- Cell Identity Switching Regulated by Retinoic Acid Signaling Maintains Homogeneous Segments in the Hindbrain.Developmental cell · 2018Article
- Establishing sharp and homogeneous segments in the hindbrain.F1000Research · 2018Review
- The gene regulatory networks underlying formation of the auditory hindbrain.Cellular and molecular life sciences : CMLS · 2015Review
- The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators.EMBO reports · 2011Article
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3 authors at 2 institutions in 1 country.
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Abstract
The zinc finger transcription factor Krox20 plays an essential role in the vertebrate hindbrain segmentation process. It positively or negatively controls a large variety of other regulatory genes, coordinating delimitation of segmental territories, specification of their identity, and maintenance of their integrity. We have investigated the molecular mechanisms of Krox20 transcriptional control by performing a detailed structure-function analysis of the protein in the developing chick hindbrain. This revealed an unsuspected diversity in the modes of action of a transcription factor in a single tissue, since regulation of each of the five tested target genes requires different parts of the protein and/or presumably different co-factors. The multiplicity of Krox20 functions might rely on this diversity. Investigation of known Krox20 co-factors was initiated in relation to this analysis. Nab was shown to act as a negative feedback modulator of the different Krox20 activating functions in the hindbrain. HCF-1 was found to bind to a Krox20 N-terminal region, which was shown to rely on multiple elements, including acidic domains, to convey Nab activation and Krox20 autoregulation.
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