ArticleGenome research2009
Global distribution of genomic diversity underscores rich complex history of continental human populations.
Article in Genome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
100 citing papers in PubMed.
- A genomic tale of inbreeding in western Mediterranean human populations.Human genetics · 2025Article
- Causal interpretations of family GWAS in the presence of heterogeneous effects.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Causal interpretations of family GWAS in the presence of heterogeneous effects.bioRxiv : the preprint server for biology · 2023Article
- Haplotyping-Assisted Diploid Assembly and Variant Detection with Linked Reads.Methods in molecular biology (Clifton, N.J.) · 2023Review
- An HLA map of the world: A comparison of HLA frequencies in 200 worldwide populations reveals diverse patterns for class I and class II.Frontiers in genetics · 2023Article
- Analysis of Common SNPs across Continents Reveals Major Genomic Differences between Human Populations.Genes · 2022Article
- Genomic consequences of a century of inbreeding and isolation in the Danish wild boar population.Evolutionary applications · 2022Article
- Joint estimation of selection intensity and mutation rate under balancing selection with applications to HLA.Genetics · 2022Article
- Landscape and Climatic Variations Shaped Secondary Contacts amid Barn Owls of the Western Palearctic.Molecular biology and evolution · 2022Article
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- Parental relatedness through time revealed by runs of homozygosity in ancient DNA.Nature communications · 2021Article
- Analysis of Homozygous-by-Descent (HBD) Segments for Purebred and Crossbred Pigs in Russia.Life (Basel, Switzerland) · 2021Article
- The impact of identity by descent on fitness and disease in dogs.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Population-Specific Genetic and Expression Differentiation in Europeans.Genome biology and evolution · 2020Article
- Population Histories of the United States Revealed through Fine-Scale Migration and Haplotype Analysis.American journal of human genetics · 2020Article
- Population genetic simulation study of power in association testing across genetic architectures and study designs.Genetic epidemiology · 2020Article
- Signatures of selection in the genome of Swedish warmblood horses selected for sport performance.BMC genomics · 2019Article
- A western route of prehistoric human migration from Africa into the Iberian Peninsula.Proceedings. Biological sciences · 2019Article
- Understanding the Hidden Complexity of Latin American Population Isolates.American journal of human genetics · 2018Article
- Complex genetic patterns in human arise from a simple range-expansion model over continental landmasses.PloS one · 2018Article
40 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors.
Funding
Abstract
Characterizing patterns of genetic variation within and among human populations is important for understanding human evolutionary history and for careful design of medical genetic studies. Here, we analyze patterns of variation across 443,434 single nucleotide polymorphisms (SNPs) genotyped in 3845 individuals from four continental regions. This unique resource allows us to illuminate patterns of diversity in previously under-studied populations at the genome-wide scale including Latin America, South Asia, and Southern Europe. Key insights afforded by our analysis include quantifying the degree of admixture in a large collection of individuals from Guadalajara, Mexico; identifying language and geography as key determinants of population structure within India; and elucidating a north-south gradient in haplotype diversity within Europe. We also present a novel method for identifying long-range tracts of homozygosity indicative of recent common ancestry. Application of our approach suggests great variation within and among populations in the extent of homozygosity, suggesting both demographic history (such as population bottlenecks) and recent ancestry events (such as consanguinity) play an important role in patterning variation in large modern human populations.
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