ArticleJournal of bacteriology2009
An Aeromonas caviae genomic island is required for both O-antigen lipopolysaccharide biosynthesis and flagellin glycosylation.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 56 citations in OpenAlex.
- Flagellar glycosylation with pseudaminic acids is widespread in the genus Clostridium.BMC microbiology · 2026Article
- Characterization of the role of putativeJournal of bacteriology · 2026Article
- Harnessing the acceptor substrate promiscuity of Clostridium botulinum Maf glycosyltransferase to glyco-engineer mini-flagellin protein chimeras.Communications biology · 2024Article
- Heterogeneous glycosylation and methylation of the Aeromonas caviae flagellin.MicrobiologyOpen · 2022Article
- Surface Glucan Structures inMarine drugs · 2021Review
- Glycosyltransferase Jhp0106 (PseE) contributes to flagellin maturation in Helicobacter pylori.Helicobacter · 2021Article
- Reconstitution and optimisation of the biosynthesis of bacterial sugar pseudaminic acid (Pse5Ac7Ac) enables preparative enzymatic synthesis of CMP-Pse5Ac7Ac.Scientific reports · 2021Article
- Prediction and AnalysisFrontiers in microbiology · 2021Article
- Metabolic Glycan Labeling-Based Screen to Identify Bacterial Glycosylation Genes.ACS infectious diseases · 2020Article
- Article
- Polar Flagella Glycosylation inFrontiers in microbiology · 2020Article
- Draft Whole-Genome Sequences of 10Microbiology resource announcements · 2019Article
- Emerging facets of prokaryotic glycosylation.FEMS microbiology reviews · 2017Review
- Article
- Cross-Talk between the Aeromonas hydrophila Type III Secretion System and Lateral Flagella System.Frontiers in microbiology · 2016Article
- The Aeromonas caviae AHA0618 gene modulates cell length and influences swimming and swarming motility.MicrobiologyOpen · 2015Article
- O-Glycosylation of the N-terminal region of the serine-rich adhesin Srr1 of Streptococcus agalactiae explored by mass spectrometry.Molecular & cellular proteomics : MCP · 2014Article
- Maf-dependent bacterial flagellin glycosylation occurs before chaperone binding and flagellar T3SS export.Molecular microbiology · 2014Article
- Gram-negative flagella glycosylation.International journal of molecular sciences · 2014Review
- Posttranslational modification of flagellin FlaB in Shewanella oneidensis.Journal of bacteriology · 2013Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Aeromonas caviae Sch3N possesses a small genomic island that is involved in both flagellin glycosylation and lipopolysaccharide (LPS) O-antigen biosynthesis. This island appears to have been laterally acquired as it is flanked by insertion element-like sequences and has a much lower G+C content than the average aeromonad G+C content. Most of the gene products encoded by the island are orthologues of proteins that have been shown to be involved in pseudaminic acid biosynthesis and flagellin glycosylation in both Campylobacter jejuni and Helicobacter pylori. Two of the genes, lst and lsg, are LPS specific as mutation of them results in the loss of only a band for the LPS O-antigen. Lsg encodes a putative Wzx flippase, and mutation of Lsg affects only LPS; this finding supports the notion that flagellin glycosylation occurs within the cell before the flagellins are exported and assembled and not at the surface once the sugar has been exported. The proteins encoded by flmA, flmB, neuA, flmD, and neuB are thought to make up a pseudaminic acid biosynthetic pathway, and mutation of any of these genes resulted in the loss of motility, flagellar expression, and a band for the LPS O-antigen. Furthermore, pseudaminic acid was shown to be present on both flagellin subunits that make up the polar flagellum filament, to be present in the LPS O-antigen of the A. caviae wild-type strain, and to be absent from the A. caviae flmD mutant strain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.