ReviewAmerican journal of physiology. Lung cellular and molecular physiology2009
Recent advances in genetic predisposition to clinical acute lung injury.
Review in American journal of physiology. Lung cellular and molecular physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Scandinavian clinical practice guideline on fluid and drug therapy in adults with acute respiratory distress syndrome.Acta anaesthesiologica Scandinavica · 2016Guideline
- Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin.Journal of medical genetics · 2012Pooled it
- Xanthine oxidoreductase gene polymorphisms are associated with high risk of sepsis and organ failure.Respiratory research · 2023Article
- Article
- Δ9-Tetrahydrocannabinol Prevents Mortality from Acute Respiratory Distress Syndrome through the Induction of Apoptosis in Immune Cells, Leading to Cytokine Storm Suppression.International journal of molecular sciences · 2020Article
- Endothelial stromelysin1 regulation by the forkhead box-O transcription factors is crucial in the exudative phase of acute lung injury.Pharmacological research · 2019Article
- Pathogenesis of Acute Respiratory Distress Syndrome.Seminars in respiratory and critical care medicine · 2019Review
- Article
- Diagnostic indicator of acute lung injury for pediatric critically ill patients at a tertiary pediatric hospital.Medicine · 2018Observational
- Messenger RNA sequencing reveals similar mechanisms between neonatal and acute respiratory distress syndrome.Molecular medicine reports · 2018Article
- Alternative pre-mRNA splicing of Toll-like receptor signaling components in peripheral blood mononuclear cells from patients with ARDS.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Experimental Lung Injury Reduces Krüppel-like Factor 2 to Increase Endothelial Permeability via Regulation of RAPGEF3-Rac1 Signaling.American journal of respiratory and critical care medicine · 2017Article
- ANLN truncation causes a familial fatal acute respiratory distress syndrome in Dalmatian dogs.PLoS genetics · 2017Article
- The pattern recognition molecule collectin-L1 in critically ill children.Pediatric research · 2016Article
- Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome.Critical care (London, England) · 2016Article
- Extremes of Interferon-Stimulated Gene Expression Associate with Worse Outcomes in the Acute Respiratory Distress Syndrome.PloS one · 2016Article
- Beyond single-nucleotide polymorphisms: genetics, genomics, and other 'omic approaches to acute respiratory distress syndrome.Clinics in chest medicine · 2014Review
- Article
- Applying metabolomics to uncover novel biology in ARDS.American journal of physiology. Lung cellular and molecular physiology · 2014Review
- Article
Corrections and comments
- Commented on by
Authors and funding
2 authors.
Funding
Abstract
It has been well established that acute lung injury (ALI), and the more severe presentation of acute respiratory distress syndrome (ARDS), constitute complex traits characterized by a multigenic and multifactorial etiology. Identification and validation of genetic variants contributing to disease susceptibility and severity has been hampered by the profound heterogeneity of the clinical phenotype and the role of environmental factors, which includes treatment, on outcome. The critical nature of ALI and ARDS, compounded by the impact of phenotypic heterogeneity, has rendered the amassing of sufficiently powered studies especially challenging. Nevertheless, progress has been made in the identification of genetic variants in select candidate genes, which has enhanced our understanding of the specific pathways involved in disease manifestation. Identification of novel candidate genes for which genetic association studies have confirmed a role in disease has been greatly aided by the powerful tool of high-throughput expression profiling. This article will review these studies to date, summarizing candidate genes associated with ALI and ARDS, acknowledging those that have been replicated in independent populations, with a special focus on the specific pathways for which candidate genes identified so far can be clustered.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.