ReviewMolecular human reproduction2009
Germ cell sex determination in mammals.
Review in Molecular human reproduction, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 111 citations in OpenAlex.
- Post-transcriptional suppression of the pioneer factor Zelda protects the adult Drosophila testis from activation of the ovary program.PLoS biology · 2025Article
- Diaph1 knockout inhibits mouse primordial germ cell proliferation and affects gonadal development.Reproductive biology and endocrinology : RB&E · 2024Article
- Analysis of Meiotic Progression by Ex Vivo Culture of Mouse Embryonic Ovaries.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Article
- Dissecting the initiation of female meiosis in the mouse at single-cell resolution.Cellular and molecular life sciences : CMLS · 2021Article
- Meiosis occurs normally in the fetal ovary of mice lacking all retinoic acid receptors.Science advances · 2020Article
- Retinoic acid synthesis by ALDH1A proteins is dispensable for meiosis initiation in the mouse fetal ovary.Science advances · 2020Article
- Evaluation of specific germ cell genes expression in mouse embryonic stem cell-derived germ cell like cells treated with bone morphogenetic protein 4 in vitro.International journal of reproductive biomedicine · 2018Article
- FOXL2 and DMRT1L Are Yin and Yang Genes for Determining Timing of Sex Differentiation in the Bivalve MolluskFrontiers in physiology · 2018Article
- Mutation analysis of NANOS3 in Brazilian women with primary ovarian failure.Clinics (Sao Paulo, Brazil) · 2016Article
- Integrative epigenomic analysis reveals unique epigenetic signatures involved in unipotency of mouse female germline stem cells.Genome biology · 2016Article
- Perchlorate Exposure Reduces Primordial Germ Cell Number in Female Threespine Stickleback.PloS one · 2016Article
- Oocyte development, meiosis and aneuploidy.Seminars in cell & developmental biology · 2015Review
- Early depletion of primordial germ cells in zebrafish promotes testis formation.Stem cell reports · 2015Article
- Vasa identifies germ cells and critical stages of oogenesis in the Asian seabass.International journal of biological sciences · 2014Article
- Oocyte differentiation is genetically dissociable from meiosis in mice.Nature genetics · 2013Article
- Identifying disruptors of male germ cell development by small molecule screening in ex vivo gonad cultures.BMC research notes · 2013Article
- The involvement of proliferation and apoptosis in the early human gonad development.Journal of molecular histology · 2013Article
- Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development.PloS one · 2013Article
- The rise of testicular germ cell tumours: the search for causes, risk factors and novel therapeutic targets.F1000Research · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
One of the major decisions that germ cells make during their development is whether to differentiate into oocytes or sperm. In mice, the germ cells' decision to develop as male or female depends on sex-determining signalling molecules in the embryonic gonadal environment rather than the sex chromosome constitution of the germ cells themselves. In response to these sex-determining cues, germ cells in female embryos initiate oogenesis and enter meiosis, whereas germ cells in male embryos initiate spermatogenesis and inhibit meiosis until after birth. However, it is not clear whether the signalling molecules that mediate germ cell sex determination act in the developing testis or the developing ovary, or what these signalling molecules might be. Here, we review the evidence for the existence of meiosis-inducing and meiosis-preventing substances in the developing gonad, and more recent studies aimed at identifying these molecules in mice. In addition, we discuss the possibility that some of the reported effects of these factors on germ cell development may be indirect consequences of impairing sexual differentiation of gonadal somatic cells or germ cell survival. Understanding the molecular mechanisms of germ cell sex determination may provide candidate genes for susceptibility to germ cell tumours and infertility in humans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.