Mammalian PGRPs in the spotlight.

Ivo Gomperts Boneca

Open access · bronzeAbstract readCommentReview

In one paragraph

Review in Cell host & microbe, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it

0cells of the map it votes in

8citing papers in PubMed

0.5field-weighted citation impact, top 36% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

Mammals' humoral immune proteins and peptides targeting the bacterial envelope: from natural protection to therapeutic applications against multidrug-resistant Gram-negatives.Biological reviews of the Cambridge Philosophical Society · 2022
Review
Gut microbiota is essential in PGRP-LA regulated immune protection against Plasmodium berghei infection.Parasites & vectors · 2020
Article
Interplay between Peptidoglycan Biology and Virulence in Gram-Negative Pathogens.Microbiology and molecular biology reviews : MMBR · 2018
Review
Targeting the permeability barrier and peptidoglycan recycling pathways to disarm Pseudomonas aeruginosa against the innate immune system.PloS one · 2017
Article
PGRP negatively regulates NOD-mediated cytokine production in rainbow trout liver cells.Scientific reports · 2016
Article
Hepatocytes: a key cell type for innate immunity.Cellular & molecular immunology · 2016
Review
Host-guest chemistry of the peptidoglycan.Journal of medicinal chemistry · 2010
Article
Transcriptome analysis describing new immunity and defense genes in peripheral blood mononuclear cells of rheumatoid arthritis patients.PloS one · 2009
Article

4 · The record

Corrections and comments

Comment on
PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation.2009

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Ivo Gomperts BonecaInstitut Pasteur, Group of Biology and Genetics of the Bacterial Cell Wall, Paris, France. bonecai@pasteur.fr

Inserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peptidoglycan-recognition proteins (PGRPs) play a central role in the insect innate immune response to bacteria. In this issue of Cell Host & Microbe, Saha et al. (2009) report that the mammalian PGRP, PGLYRP-2, functions as a cytokine-like molecule in a PG-induced arthritis model.

Indexed as

AnimalsArthritisBacteriaBacterial InfectionsMammalsMiceN-Acetylmuramoyl-L-alanine AmidaseProteinsN-Acetylmuramoyl-L-alanine AmidasePglyrp2 protein, mouseProteins

Identifiers

PMID19218081

DOI10.1016/j.chom.2009.01.007

OpenAlexW2048503939

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.