Evidence map›Paper›PMID 19217909›Full record

ReviewInternational journal for parasitology2009

Sexual recombination punctuated by outbreaks and clonal expansions predicts Toxoplasma gondii population genetics.

Michael E Grigg, Natarajan Sundar

Open access · greenAbstract readReview
In one paragraph

Review in International journal for parasitology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 109 citations in OpenAlex.

  1. Article
  2. FEMS microbes · 2026
    Article
  3. Molecular detection and characterisation ofInternational journal for parasitology. Parasites and wildlife · 2025
    Article
  4. Article
  5. Article
  6. Seroprevalence and Genetic Characterization ofJournal of tropical medicine · 2022
    Article
  7. Article
  8. Frontiers in cellular and infection microbiology · 2021
    Article
  9. International journal for parasitology. Parasites and wildlife · 2020
    Article
  10. White-tailed deer (Parasitology · 2020
    Article
  11. Article
  12. Article
  13. Article
  14. Global selective sweep of a highly inbred genome of the cattle parasiteProceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  15. Diversity ofFood and waterborne parasitology · 2019
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Michael E GriggMolecular Parasitology Unit, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD 20815, USA. griggm@niaid.nih.gov
Natarajan Sundar
National Institutes of Health · US

Funding

Toxoplasma Population GeneticsZIAAI001018 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GRIGG, MICHAEL · 2009 to 2025
$11.3M
Toxoplasma Population GeneticsZ01AI001018 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI GRIGG, MICHAEL · 2007 to 2008
$801k
Intramural NIH HHS Z01 AI001018
6 · The paper itself

Abstract

The cosmopolitan parasitic pathogen Toxoplasma gondii is capable of infecting essentially any warm-blooded vertebrate worldwide, including most birds and mammals, and establishes chronic infections in one-third of the globe's human population. The success of this highly prevalent zoonosis is largely the result of its ability to propagate both sexually and clonally. Frequent genetic exchanges via sexual recombination among extant parasite lineages that mix in the definitive felid host produces new lines that emerge to expand the parasite's host range and cause outbreaks. Highly successful lines spread clonally via carnivorism and in some cases sweep to pandemic levels. The extent to which sexual reproduction versus clonal expansion shapes Toxoplasma's current, global population genetic structure is the central question this review will attempt to answer.

Indexed as

Disease OutbreaksGenetics, PopulationLife Cycle StagesAmericasAnimalsCatsEuropeForecastingGene FrequencyGenes, ProtozoanGenetic VariationHumansKoreaMeiosisOocystsPhylogeny

Identifiers

PMID19217909
PMCPMC2713429
OpenAlexW1970232099

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.