ArticleDevelopmental biology2009
Regulation of mouse embryonic stem cell neural differentiation by retinoic acid.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed.
- Signalling through RXRβ and its agonist, bexarotene, promotes neuron formation in Xenopus laevis embryos.Biology open · 2026Article
- Locat: Joint enrichment and depletion testing identifies localized marker genes in single-cell transcriptomics.bioRxiv : the preprint server for biology · 2026Article
- Hiding in plain sight: NUT carcinoma is an unrecognized subtype of squamous cell carcinoma of the lungs and head and neck.Nature reviews. Clinical oncology · 2025Review
- Incomplete Elongation of Ultra-long-chain Polyunsaturated Acyl-CoAs by the Fatty Acid Elongase ELOVL4 in Spinocerebellar Ataxia Type 34.Molecular and cellular biology · 2023Article
- Signaling through retinoic acid receptors is essential for mammalian uterine receptivity and decidualization.JCI insight · 2021Article
- Induction of Ventral Spinal V0 Interneurons from Mouse Embryonic Stem Cells.Stem cells and development · 2021Article
- Axial elongation of caudalized human organoids mimics aspects of neural tube development.Development (Cambridge, England) · 2021Article
- SOX Transcription Factors in Endothelial Differentiation and Endothelial-Mesenchymal Transitions.Frontiers in cardiovascular medicine · 2019Article
- Derivation of Specific Neural Populations From Pluripotent Cells for Understanding and Treatment of Spinal Cord Injury.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Review
- Stem cell colony interspacing effect on differentiation to neural cells.Journal of tissue engineering and regenerative medicine · 2018Article
- An Alternative Method for Long-Term Culture of Chicken Embryonic Stem CellStem cells international · 2018Article
- Effects of light emitting diode irradiation on neural differentiation of human umbilical cord-derived mesenchymal cells.Scientific reports · 2017Article
- Self-regulatory factors of embryonic stem cells in co-culture with stromal cells enhance neural differentiation.Integrative biology : quantitative biosciences from nano to macro · 2017Article
- Stem cells for spinal cord injury: Strategies to inform differentiation and transplantation.Biotechnology and bioengineering · 2017Review
- Medial Ganglionic Eminence Cells Freshly Obtained or Expanded as Neurospheres Show Distinct Cellular and Molecular Properties in Reducing Epileptic Seizures.CNS neuroscience & therapeutics · 2017Article
- Vitamin E-Mediated Modulation of Glutamate Receptor Expression in an Oxidative Stress Model of Neural Cells Derived from Embryonic Stem Cell Cultures.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis.eLife · 2016Article
- Article
- An essential role for UTX in resolution and activation of bivalent promoters.Nucleic acids research · 2016Article
- Valosin-containing protein is a key mediator between autophagic cell death and apoptosis in adult hippocampal neural stem cells following insulin withdrawal.Molecular brain · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Pluripotent mouse embryonic stem cells (ESCs) derived from the early blastocyst can differentiate in vitro into a variety of somatic cell types including lineages from all three embryonic germ layers. Protocols for ES cell neural differentiation typically involve induction by retinoic acid (RA), or by exposure to growth factors or medium conditioned by other cell types. A serum-free differentiation (SFD) medium completely lacking exogenous retinoids was devised that allows for efficient conversion of aggregated mouse ESCs into neural precursors and immature neurons. Neural cells produced in this medium express neuronal ion channels, establish polarity, and form functional excitatory and inhibitory synapses. Brief exposure to RA during the period of cell aggregation speeds neuronal maturation and suppresses cell proliferation. Differentiation without RA yields neurons and neural progenitors with apparent telencephalic identity, whereas cells differentiated with exposure to RA express markers of hindbrain and spinal cord. Transcriptional profiling indicates a substantial representation of transit amplifying neuroblasts in SFD cultures not exposed to RA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.